The salting-out extraction (SOE) systems based on ionic liquids (ILs) have attracted extensive attention in the separation of bio-based products, in which imidazolium ILs were widely studied. However, the high cost and toxicity have hindered their further industrial application. Hydroxylammonium ILs have the characteristics of cheap raw material, simple synthesis process and low toxicity, but are rarely used in the SOE systems. In this work, five hydroxylammonium ILs (2 cations and 4 carboxylate anions) were synthesized and used in SOE of bio-chemicals. The phase forming abilities of ILs with K₃PO₄ and H₂O were affected by the hydrophilicity of anions and cations. With the increase of carbon chain length, phase forming abilities of ILs increased, while the temperature had little influence. The partition behaviors of acetoin, ILs and 2,3-butandiol, and the selectivity of acetoin to organic acids were investigated and compared at different concentrations of ethanolammonium butyrate (EOAB) and K₃PO₄. In a SOE system consisted of 6% EOAB-38% K₃PO₄ (w/w), the recovery of acetoin, IL and 2,3-butandiol was 92.7%, 76.0% and 86.0%, respectively, and the selectivity of acetoin to lactic acid and acetic acid was 16.46 and 3.85, respectively. The ATR-IR spectra showed the hydrogen bonds formed between acetoin and O-H, N-H, -COO^- of hydroxylammonium IL played an important role in the efficient extraction of acetoin from fermentation broths.

基于离子液体（IL）的盐析萃取（SOE）系统在生物基产品的分离中引起了广泛的关注，其中对咪唑类ILs进行了广泛的研究。然而，高成本和毒性阻碍了它们的进一步工业应用。羟基铵离子液体具有原料便宜，合成工艺简单，毒性低的特点，但很少在SOE系统中使用。在这项工作中，合成了五个羟基铵ILs（2个阳离子和4个羧酸根阴离子）并将其用于生化产品的SOE。具有K ₃ PO ₄和H ₂的IL的相形成能力O受阴离子和阳离子的亲水性影响。随着碳链长度的增加，离子液体的相形成能力增加，而温度的影响很小。在不同浓度的丁酸乙醇铵（EOAB）和K ₃ PO _4下，研究并比较了乙醛，IL和2,3-丁二醇的分配行为，以及乙醛对有机酸的选择性。在由6％EOAB-38％K ₃ PO ₄（w / w）组成的SOE系统中，乙醛，IL和2,3-丁二醇的回收率分别为92.7％，76.0％和86.0％，且选择性为乙酰乙酸对乳酸和乙酸的分别为16.46和3.85。的ATR-IR光谱显示出乙偶姻和OH，NH，-COO之间形成的氢键^- 羟铵IL的含量在从发酵液中高效提取乙醛中起着重要作用。