Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids.,Molecular Nutrition & Food Research

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Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-02-06 , DOI: 10.1002/mnfr.201900616
Iñaki Robles-Vera ₁ , Marta Toral _{2,

3} , Néstor de la Visitación ₁ , Manuel Sánchez _{1,

4} , Manuel Gómez-Guzmán _{1,

4} , Miguel Romero _{1,

4} , Tao Yang _{5,

6} , José L Izquierdo-Garcia ₇ , Rosario Jiménez _{1,

3,

4} , Jesús Ruiz-Cabello ₇ , Eduardo Guerra-Hernández ₈ , Mohan K Raizada ₅ , Francisco Pérez-Vizcaíno ₉ , Juan Duarte _{1,

3,

4}

Affiliation

Department of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain.
Gene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029, Madrid, Spain.
CIBERCV, Spain.
Instituto de Investigación Biosanitaria de Granada, 18016, Granada, Spain.
Department of Physiology and Functional Genomics, University of Florida, Gainesville, 32610, FL, USA.
Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, 43606.
CIC biomaGUNE, Donostia-San Sebastián, 20014, Spain.
Department of Nutrition and Bromatology, University of Granada, 18071, Granada, Spain.
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid, Ciber Enfermedades Respiratorias (Ciberes), Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), 28040, Madrid, Spain.

The objective of this study is to determine the cardiovascular effects of the probiotics Bifidobacterium breve CECT7263 (BFM) and Lactobacillus fermentum CECT5716 (LC40), and the short chain fatty acids butyrate, and acetate in spontaneously hypertensive rats (SHR).

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