Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular processes and multiple human diseases mediated by misregulation of PPIn signaling. This review will present a timely summary of recent discoveries in PPIn biology, specifically their role in regulating unexpected signaling pathways, modification of signaling outcomes downstream of integral membrane proteins, and novel roles in lipid transport. This has revealed new roles of PPIns in regulating membrane trafficking, immunity, cell polarity, and response to extracellular signals. A specific focus will be on novel opportunities to target PPIn metabolism for treatment of human diseases, including cancer, pathogen infection, developmental disorders, and immune disorders.

中文翻译：

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磷酸肌醇在信号传导，脂质转运和疾病中的新作用。

磷脂酰肌醇（PPIns）是作为细胞信号转导的主要调节剂的脂质信号转导分子。最近的研究揭示了PPIns在无数细胞过程和由PPIn信号调节失调介导的多种人类疾病中的新作用。这篇综述将及时总结PPIn生物学的最新发现，特别是它们在调节意想不到的信号传导途径，修饰整合膜蛋白下游信号传导结果中的作用以及在脂质转运中的新作用。这揭示了PPIn在调节膜运输，免疫，细胞极性和对细胞外信号的反应中的新作用。将特别关注针对PPIn代谢的新机会，以治疗人类疾病，包括癌症，病原体感染，发育异常和免疫异常。