Targeted degradation is a promising new modality in drug discovery that makes it possible to reduce intracellular protein levels with small molecules. It is a complementary approach to the conventional protein knockdown typically used in laboratories and may offer a way to approach the currently undruggable human proteome. Recently, the first autophagy-mediated degraders, called AUTACs, were developed based on observations in a xenophagy study.

中文翻译：

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通过AUTAC降解剂靶向选择性自噬。

靶向降解是药物发现中一种有前途的新方法，可以通过小分子降低细胞内蛋白质水平。它是实验室中通常使用的常规蛋白质敲除的一种补充方法，并且可以提供一种方法来接近目前无法吸收的人类蛋白质组。最近，根据异种研究中的观察结果，开发了第一个自噬介导的降解剂AUTAC。