BACKGROUND Dyslipidemia is a multifactorial disorder, which arises from complex interactions among genetic and environmental risk factors. Previous studies have established the deteriorating effect of aging on lipid profiles. However, little is known about the role of education level, a stable marker of socioeconomic status, which reflect modifiability of lifestyle risk factors. Therefore, we examined the association between age and individual dyslipidemia parameter across education level among healthy, middle-aged Korean women. METHODS From 2049 middle-aged women, education attainment was classified into completion of elementary school or below, middle school, high school, college or above. Dyslipidemia was assessed in adherence to the 2018 Korean Dyslipidemia Treatment Guideline. Multivariable logistic regression and generalized linear model tested for associations between age and dyslipidemia parameter across education level and other known risk factors, including menopause, obesity, and current drinking and smoking. RESULTS In this cross-sectional analysis, the prevalence of each dyslipidemia parameter was significantly different by age and education level. The odds ratio (OR) for dyslipidemia was higher among participants who were older and had received higher education (OR = 2.31, p for interaction = 0.008) than younger and low education counterpart. The interaction between age and education level remained significant for hypercholesterolemia (p for interaction = 0.003) and hyper-LDL-cholesterolemia (p for interaction = 0.002). CONCLUSIONS Separate examination of individual dyslipidemia parameter indicated varying degree of interaction with age and education level. Such results imply that each type of lipid abnormality may arise from and be exacerbated by heterogeneous composition of biological and lifestyle risk factors, which may be reflected by education level.

中文翻译：

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年龄和血脂异常之间的关联因教育程度而异：心血管和代谢疾病病因研究中心（CMERC）队列。

背景技术血脂异常是一种多因素疾病，其由遗传和环境危险因素之间的复杂相互作用引起。先前的研究已经建立了衰老对脂质分布的恶化作用。然而，人们对教育水平的作用知之甚少，而教育水平是社会经济地位的稳定标志，反映了生活方式风险因素的可修改性。因此，我们研究了健康的中年韩国妇女在整个教育水平上年龄与血脂异常参数之间的关系。方法从2049年的中年妇女开始，将其受教育程度分为小学以下学历，初中，高中，大学以上学历。根据2018年韩国血脂异常治疗指南评估血脂异常。通过多变量logistic回归和广义线性模型，测试了受教育程度与其他已知风险因素（包括更年期，肥胖症和当前饮酒和吸烟）之间年龄和血脂异常参数之间的关联。结果在该横断面分析中，每个血脂异常参数的患病率因年龄和教育程度而有显着差异。血脂异常的比值比（OR）在年龄较大且接受过高等教育的参与者中比年轻和低学历的参与者更高（OR = 2.31，交互作用的p = 0.008）。高胆固醇血症（相互作用的p = 0.003）和高LDL-胆固醇血症（相互作用的p = 0.002）的年龄和受教育程度之间的相互作用仍然很显着。结论单独检查血脂异常参数表明与年龄和受教育程度的相互作用程度不同。这些结果表明，每种类型的脂质异常可能是由生物学和生活方式风险因素的异质组成引起的，并且由于其受教育程度的影响而加剧。