BACKGROUND Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treatment outcome and determine factors that predict a poor treatment outcome in acute heart failure patients at a Tertiary Care Hospital in Ethiopia. METHODS A prospective observational study design was used. Data were collected using a structured questionnaire as a tool. Outcome variables were assessed at the time of discharge from the hospital. Bivariate and multivariate logistic regression analyses were used to determine factors that predict in-hospital mortality. A p-value ≤0.05 was considered as statistically significant. RESULTS Out of the 169 patients, the median age of patients with acute heart failure was 34 years (IQR = 23 to 50) and median hospital stay was 4.0 days (IQR = 3.0 to 6.0). The leading precipitating factor and underlying disease at the time of admission were pneumonia (47.5%) and chronic rheumatic heart disease (48.5%), respectively. The in-hospital mortality was found to be 17.2%. Smoking (adjusted odds ratio (AOR) = 8.7, p = 0.006), diabetes mellitus (AOR = 10.2, p = 0.005), pulmonary hypertension (AOR = 4.3, p = 0.016), and the presence of adverse drug events (AOR = 4.2, p = 0.003) were predictors of in-hospital mortality. CONCLUSION High in-hospital mortality was observed among acute heart failure patients admitted to a Tertiary Care Hospital in Ethiopia. Smoking, diabetes mellitus, pulmonary hypertension and the presence of adverse drug events were predictors of in-hospital mortality.

中文翻译：

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埃塞俄比亚一家三级医院急性心力衰竭患者的治疗结果及其预测因素：一项前瞻性观察研究。

背景技术急性心力衰竭是新的或恶化的心力衰竭的体征和症状的快速发作，需要住院或去急诊室就诊。这项研究的目的是评估治疗结果并确定预测埃塞俄比亚三级护理医院急性心力衰竭患者治疗结果不良的因素。方法采用前瞻性观察研究设计。使用结构化问卷作为工具收集数据。出院时评估结果变量。使用双变量和多元逻辑回归分析来确定预测院内死亡率的因素。P值≤0.05被认为具有统计学意义。结果在169例患者中，急性心力衰竭患者的中位年龄为34岁（IQR = 23至50），中位住院时间为4.0天（IQR = 3.0至6.0）。入院时主要的促发因素和基础疾病分别是肺炎（47.5％）和慢性风湿性心脏病（48.5％）。发现住院死亡率为17.2％。吸烟（调整后的优势比（AOR）= 8.7，p = 0.006），糖尿病（AOR = 10.2，p = 0.005），肺动脉高压（AOR = 4.3，p = 0.016），以及存在不良药物事件（AOR = 4.2，p = 0.003）是住院死亡率的预测指标。结论在埃塞俄比亚三级医院住院的急性心力衰竭患者中，院内死亡率较高。吸烟，糖尿病，