BACKGROUND The cost-benefit of stocking dantrolene in maternity units for treating malignant hyperthermia (MH) has been recently questioned because of the low incidence of MH crisis in the general population and the low utilization of general anesthesia in obstetrics. However, no study has examined the prevalence of MH susceptibility in obstetrics. This study aimed to assess the prevalence of MH diagnosis and associated factors in obstetric patients. METHODS Data for this study came from the National Inpatient Sample from 2003 to 2014, a 20% nationally representative sample of discharge records from community hospitals. A diagnosis of MH due to anesthesia was identified using the International Classification of Diseases, Ninth Revision, Clinical Modification code 995.86. MH prevalence was estimated according to the delivery mode and patient and hospital characteristics. RESULTS During the 12-year study period, 47,178,322 delivery-related discharges [including 15,175,127 (32.2%) cesarean deliveries] were identified. Of them, 215 recorded a diagnosis of MH, yielding a prevalence of 0.46 per 100,000 [95% confidence interval (CI), 0.40 to 0.52]. The prevalence of MH diagnosis in cesarean deliveries was 0.81 per 100,000 (95% CI, 0.67 to 0.97), compared with 0.29 per 100,000 (95% CI, 0.23 to 0.35) in vaginal deliveries (P <  0.001). Multivariable logistic regression revealed that cesarean delivery was associated with a significantly increased risk of MH diagnosis [adjusted rate ratio (aOR) 2.88; 95% CI, 2.19 to 3.80]. Prevalence of MH diagnosis was lower in Hispanics than in non-Hispanic whites (aOR 0.47; 95% CI, 0.29 to 0.76) and higher in the South than in the Northeast census regions (aOR 2.44; 95% CI, 1.50 to 3.96). CONCLUSION The prevalence of MH-susceptibility is about 1 in 125,000 in cesarean deliveries, similar to the prevalence reported in non-obstetrical surgery inpatients. The findings of this study suggest that stocking dantrolene in maternity units is justified.

中文翻译：

---

2003年至2014年，美国产科患者的恶性高热诊断率。

背景技术由于在普通人群中MH危机的发生率低并且在产科中全身麻醉的使用率低，最近在产妇单位中储存丹特罗治疗恶性高热（MH）的成本效益受到质疑。但是，尚无研究检查MH在妇产科中的患病率。本研究旨在评估产科患者MH诊断的患病率及相关因素。方法该研究的数据来自2003年至2014年的国家住院病人样本，这是全国有代表性的社区医院出院记录样本的20％。使用《国际疾病分类》（第九版，临床修改代码995.86）确定了因麻醉导致的MH诊断。根据分娩方式以及患者和医院的特征来估计MH的患病率。结果在为期12年的研究期内，共确定了47,178,322例与分娩有关的分泌物[包括15,175,127例（32.2％）剖宫产]。其中有215例被诊断为MH，患病率为每10万人0.46 [95％置信区间（CI）为0.40至0.52]。剖宫产中MH诊断的患病率为0.81 / 10万（95％CI，0.67至0.97），阴道分娩为0.29 / 10万（95％CI，0.23至0.35）（P <0.001）。多变量logistic回归显示，剖宫产与MH诊断的风险显着增加有关[调整率比（aOR）2.88；95％CI，2.19至3.80]。西班牙裔美国人的MH诊断患病率低于非西班牙裔白人（aOR 0.47; 95％CI，0。在南部的29％至0.76）和高于东北部人口普查地区（aOR 2.44; 95％CI，1.50至3.96）。结论剖宫产的MH易感性患病率约为12.5万分之一，与非产科手术住院患者中报道的患病率相似。这项研究的结果表明，以产妇单位储存丹特罗是合理的。