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Are Finger Skin Fluorophores Other Than Advanced Glycation End Products (AGEs) Associated With Impaired Musculoskeletal Properties?
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 5.1 ) Pub Date : 2018-12-13 , DOI: 10.1093/gerona/gly280
Sho-ichi Yamagishi 1
Affiliation  

I read an interesting article by Tabara et al., which examined the association of advanced glycation end products (AGEs), evaluated by skin autofluorescence (SAF), with musculoskeletal factors in a large general population (1). In this cross-sectional study, SAF was measured on the middle finger of nondominant hand using the AGE sensor RQ-AG01J (SHARP Life Science Co., Kobe, Japan). The authors found in their Japanese cohort of 9,203 individuals that SAF was inversely associated with skeletal muscle mass index, bone mineral density evaluated by speed of sound in the calcaneal bone, and hip flexion and abduction strengths, all of which were independent of covariates, including age, sex, body mass index, C-reactive protein, and estimated glomerular filtration rate (1). AGEs have been shown to alter the structural integrity of extracellular matrix proteins in skeletal muscles and bones, whereas AGEs and their receptor RAGE interaction not only inhibit osteoblast differentiation and proliferation, but also induce muscle atrophy and dysfunction in cell culture and animal models (1–3). Moreover, SAF in the dominant forearm measured by the AGE Reader (AGE Reader-SAF) (DiagnOptics Technologies BV, Groningen, the Netherlands) has also been shown to correlate with low skeletal muscle mass as well as low skeletal muscle and bone strengths in a general population (1,2). Based on these findings, the authors conclude that accumulation of AGEs in skeletal muscles and bones might exert harmful effects on musculoskeletal systems and SAF-AGE levels measured by the AGE sensor (AGE sensor-SAF) is highly likely to be a risk marker of musculoskeletal frailty. However, I think that the following critical issues should be clarified to draw such a conclusion.

中文翻译:

除高级糖基化终产物(AGEs)以外,手指皮肤的荧光团是否与受损的骨骼肌肉特性有关?

我读了Tabara等人的一篇有趣的文章,该文章研究了通过皮肤自体荧光(SAF)评估的晚期糖基化终末产物(AGEs)与大量普通人群中的肌肉骨骼因素之间的关系(1)。在这项横断面研究中,使用AGE传感器RQ-AG01J(日本神户SHARP Life Science Co.)在非惯用手的中指上测量了SAF。作者在他们的9,203名日本人队列中发现,SAF与骨骼肌质量指数,通过跟骨骨中声速评估的骨矿物质密度以及髋部屈曲和绑架强度呈负相关,所有这些均与协变量无关,包括年龄,性别,体重指数,C反应蛋白和估计的肾小球滤过率(1)。研究表明,AGEs会改变骨骼肌和骨骼中细胞外基质蛋白的结构完整性,而AGEs及其受体RAGE相互作用不仅抑制成骨细胞的分化和增殖,而且还会在细胞培养和动物模型中诱发肌肉萎缩和功能障碍(1– 3)。此外,通过AGE Reader(AGE Reader-SAF)(DiagnOptics Technologies BV,荷兰Groningen,荷兰)测量的前臂中的SAF也已显示出与低骨骼肌质量以及低骨骼肌和骨骼强度相关。一般人口(1,2)。根据这些发现,作者得出结论,骨骼肌和骨骼中AGEs的积累可能会对肌肉骨骼系统产生有害影响,而用AGE传感器(AGE sensor-SAF)测量的SAF-AGE水平很可能是肌肉骨骼脆弱的危险标志。但是,我认为应该澄清以下关键问题才能得出这样的结论。
更新日期:2020-01-21
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