Single dose of Doxycycline for the prevention of TBRF.,Clinical Infectious Diseases

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Single dose of Doxycycline for the prevention of TBRF.
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-01-19 , DOI: 10.1093/cid/ciaa034
Yoav Binenbaum _{1,

2,

3} , Ronen Ben-Ami _{3,

4} , Gad Baneth ₅ , Boaz Langford ₆ , Yoav Negev ₆ , Edwa Friedlander ₁ , David Shasha _{3,

4} , Luba Tau _{3,

4} , Yael Paran _{3,

4}

Affiliation

The current postexposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days’ doxycycline. In this observational study of 77 spelunkers at high risk for TBRF, a single dose of 100 mg doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.

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