The aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd.

中文翻译：

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含羞草含羞草对镉中毒大鼠肝脏的治疗作用。

这项研究的目的是评估形态，氧化，炎症和诱变参数下的含羞草含羞草对暴露于镉的大鼠肝脏的治疗特性。如下将总共40只Wistar大鼠（90天，约250g）分为8组（n ＝ 5）。（ii）镉：注射量为1.2 mg / kg的氯化镉；（iii）含羞草提取物：以250 mg / kg的含羞草提取物处理；（iv）含羞草馏分：用62.5 mg / kg的乙酸含羞草馏分处理；（v）镉和含羞草提取物62.5：以1.2 mg / kg的剂量注射氯化镉，并用62.5 mg / kg的含羞草提取物处理；（vi）镉和含羞草提取物125：以1.2 mg / kg的剂量注射氯化镉，并用125 mg / kg的含羞草提取物处理；（vii）镉和含羞草250提取物：提交氯化镉1。注射2 mg / kg，并以250 mg / kg的含羞草提取物治疗；（viii）用乙酸含羞草级分处理的镉：接受氯化镉1.2 mg / kg注射，用含羞草提取物的乙酸盐级分以62.5 mg / kg的处理。在用镉中毒并用级分处理的动物中[62.5]，SOD-Mn的表达增加，除了抗诱变和抗氧化作用外，还降低了双核肝细胞，核溶解和有核溢血的频率。提取物[62.5]具有细胞保护作用，抗诱变作用和减少的核溶解作用。提取物[125]具有细胞保护性，抗氧化剂，抗纤维化，抗炎性，并减少了双核肝细胞的发生频率，而提取物[250]具有细胞毒性和致突变性。总之，含羞草的提取物在镉中毒后在肝组织中具有某些治疗作用，但仅当以中等剂量给药时。EHM [250]和Fr-EtOAc基团中的多酚含量较高，尤其是与Cd结合时，可能在肝脏中发挥促氧化剂活性。