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Estimates of cutoffs with specificities and sensitivities for urine cotinine and hydroxycotinine for US adults aged ≥ 20 years to classify smokers and nonsmokers.
Environmental Science and Pollution Research ( IF 5.8 ) Pub Date : 2020-01-17 , DOI: 10.1007/s11356-020-07710-x
Ram Baboo Jain 1
Affiliation  

Data for urine cotinine and hydroxycotinine became available for the first time in the 2013-2014 cycle of the National Health and Nutrition Examination Survey administered by the US Centers for Disease Control and Prevention. Cutoffs to classify smokers and nonsmokers for both cotinine and hydroxycotinine for US adults aged ≥ 20 years were developed by using receiver operating characteristic curve methodology. The optimality criterion used to determine cutoffs simultaneously maximized both specificity and sensitivity. Cutoffs were determined for the total population, males, females, non-Hispanic whites, non-Hispanic blacks, Hispanics, and non-Hispanic Asians. Cutoffs for both cotinine and hydroxycotinine were determined with a minimum sensitivity of 95.5% and with a minimum specificity of 95.4%. For the total population, cutoff for urine cotinine was 91.7 ng/mL estimated with a specificity as well as a sensitivity of 97.1%. The cutoff for the total population for urine hydroxycotinine was 128.0 ng/mL estimated with a specificity as well as a sensitivity of 96.5%. The order in which cutoffs were observed for cotinine was non-Hispanic blacks (283.0 ng/mL) > non-Hispanic whites (111.0 ng/mL) > males (109.0 ng/mL) > females (91.7 ng/mL) > total population (91.7 ng/mL) > Hispanics (20.8 ng/mL) > non-Hispanic Asians (7.39 ng/mL). The order in which cutoffs were observed for hydroxycotinine was non-Hispanic blacks (530.0 ng/mL) > non-Hispanic whites (180.0 ng/mL) > females (97.0 ng/mL) > total population (96.5 ng/mL) > males (95.9 ng/mL) > Hispanics (20.6 ng/mL) > non-Hispanic Asians (13.8 ng/mL). Thus, the largest cutoffs were observed for non-Hispanic blacks and the lowest cutoffs were observed for non-Hispanic Asians.

中文翻译:

对于年龄≥20岁的美国成年人,对尿可替宁和羟可卡因的特异性和敏感性的临界值进行估计,以对吸烟者和非吸烟者进行分类。

尿可替宁和羟可卡因的数据在美国疾病控制与预防中心进行的2013年至2014年国家健康与营养检查调查周期中首次获得。通过使用受试者工作特征曲线方法,对年龄≥20岁的美国成年人进行了可替宁和羟烟碱分类吸烟者和非吸烟者的分类标准。用于确定临界值的最佳标准同时使特异性和敏感性最大化。确定了总人口,男性,女性,非西班牙裔白人,非西班牙裔黑人,西班牙裔和非西班牙裔亚裔的临界值。测定可替宁和羟可宁的临界值时,最低灵敏度为95.5%,最低特异性为95.4%。对于总人口来说 尿可替宁的截断值为91.7 ng / mL,有特异性,灵敏度为97.1%。尿羟可卡因的总人群的临界值为128.0 ng / mL,估计有特异性,敏感性为96.5%。观察到可替宁截止的顺序为非西班牙裔黑人(283.0 ng / mL)>非西班牙裔白人(111.0 ng / mL)>男性(109.0 ng / mL)>女性(91.7 ng / mL)>总人口(91.7 ng / mL)>西班牙裔(20.8 ng / mL)>非西班牙裔亚洲人(7.39 ng / mL)。观察到的羟烟碱截留的顺序是非西班牙裔黑人(530.0 ng / mL)>非西班牙裔白人(180.0 ng / mL)>女性(97.0 ng / mL)>总人口(96.5 ng / mL)>男性(95.9 ng / mL)>西班牙裔(20.6 ng / mL)>非西班牙裔亚洲人(13.8 ng / mL)。从而,
更新日期:2020-01-17
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