Inhibitory signaling on T cells maintains “naïvety” to self-antigen The adaptive immune system, with T and B lymphocytes being its two principal cell types, enables efficient protection from countless pathogens. T lymphocytes emerge from the thymus as quiescent (noncycling) naïve cells and display an immense repertoire of clonally distributed T cell receptors (TCRs) that detect antigens and are generated as the result of a largely random process of somatic gene rearrangement in thymic precursor cells. On page 264 of this issue, ElTanbouly et al. (1) show that naïve T cell quiescence is actively regulated upon their egress from the thymus and that this may be critical for constraining self-reactive T cells and preventing autoimmunity.

中文翻译：

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强制执行 T 细胞无罪

T 细胞上的抑制性信号传导保持对自身抗原的“天真”适应性免疫系统，T 和 B 淋巴细胞是其两种主要细胞类型，能够有效保护免受无数病原体的侵害。T 淋巴细胞作为静止（非循环）幼稚细胞从胸腺中出现，并显示出大量克隆分布的 T 细胞受体 (TCR)，这些受体可检测抗原，并且是胸腺前体细胞中体细胞基因重排的随机过程的结果。在本期第 264 页上，ElTanbouly 等人。(1) 表明幼稚 T 细胞静止在它们从胸腺排出时受到主动调节，这可能对限制自我反应性 T 细胞和预防自身免疫至关重要。