Background and Purpose—There are few large studies examining comorbidities, outcomes, and acute interventions for patients with retinal artery occlusion (RAO). RAO shares pathophysiology with acute ischemic stroke (AIS); direct comparison may inform emergent treatment, evaluation, and secondary prevention.Methods—The National Readmissions Database contains data on ≈50% of US hospitalizations from 2013 to 2015. We used International Classification of Diseases, Ninth Revision, codes to identify and compare index RAO and AIS admissions, comorbidities, and interventions and Clinical Comorbidity Software codes to identify readmissions causes, using survey-weighted methods when possible. Cumulative risk of all-cause readmission after RAO ≤1 year was estimated by Kaplan-Meier analysis.Results—Among 4871 RAO and 1 239 963 AIS admissions, patients with RAO were less likely (P<0.0001) than patients with AIS to have diabetes mellitus (RAO, 24.3% versus AIS, 36.8%), congestive heart failure (9.1% versus 14.8%), atrial fibrillation (15.5% versus 25.2%), or hypertension (62.2% versus 67.6%) but more likely to have valvular disease (13.3% versus 10.5%) and tobacco usage (38.6% versus 32.9%). In RAO admissions, thrombolysis was administered in 2.9% (5.8% in central RAO subgroup, versus 8.0% of AIS), therapeutic anterior chamber paracentesis in 1.0%, thrombectomy in none; 1.4% received carotid endarterectomy during index admission, 1.6% within 30 days. Nearly 1 in 10 patients with RAO were readmitted within 30 days and were more than twice as likely as patients with AIS to be readmitted for dysrhythmia or endocarditis. Readmission for stroke after RAO was the highest within the first 150 days after index admission, and risk was higher in central RAO than in branch RAO.Conclusions—Patients with RAO had high prevalence of many stroke risk factors, particularly valvular disease and smoking, which can be addressed to minimize subsequent risk. Despite less baseline atrial fibrillation, RAO patients were more likely to be readmitted for atrial fibrillation/dysrhythmias. A variety of interventions was administered. AIS risk is the highest shortly after RAO, emphasizing the importance of urgent, thorough neurovascular evaluation.

中文翻译：

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视网膜动脉闭塞的特征和结果：全国代表性数据。

背景和目的-很少有大型研究检查视网膜动脉阻塞（RAO）患者的合并症，结局和急性干预措施。RAO与急性缺血性中风（AIS）共享病理生理学；直接比较可以为紧急治疗，评估和二级预防提供依据。方法—国家再入院数据库包含2013年至2015年约50％的美国住院患者的数据。我们使用了《国际疾病分类》（第九版），用于识别和比较RAO和AIS指数入院，合并症和干预措施的代码，以及临床合并症软件代码，用于在可能的情况下使用调查加权方法来识别再入院原因。通过Kaplan-Meier分析估计了RAO≤1年后全因再入院的累积风险。结果-在4871 RAO和1 239 963 AIS入院中，RAO患者的可能性较小（P<0.0001）比患有AIS的患者患有糖尿病（RAO，24.3％vs AIS，36.8％），充血性心力衰竭（9.1％vs 14.8％），房颤（15.5％vs 25.2％）或高血压（62.2％vs 67.6％），但更可能患有瓣膜病（13.3％对10.5％）和烟草使用（38.6％对32.9％）。在RAO入院时，溶栓发生率为2.9％（中央RAO亚组为5.8％，而AIS为8.0％），治疗性前房穿刺穿刺术为1.0％，无血栓切除术。在入院期间接受颈动脉内膜切除术的患者为1.4％，在30天内接受颈动脉内膜切除术的患者为1.6％。在30天内，有十分之一的RAO患者被再入院，而因心律不齐或心内膜炎而被重新接纳的AIS的可能性是AIS患者的两倍。RAO后的中风再入院率在指数入院后的前150天内最高，结论—患有RAO的患者在许多中风危险因素中普遍存在，尤其是瓣膜疾病和吸烟，可以通过降低患病风险来解决。尽管基线房颤较少，但RAO患者更可能因房颤/心律失常而再次入院。进行了各种干预。在发生RAO之后不久，AIS风险最高，强调了紧急，彻底的神经血管评估的重要性。RAO患者更有可能因房颤/心律不齐而再次入院。进行了各种干预。在发生RAO之后不久，AIS风险最高，强调了紧急，彻底的神经血管评估的重要性。RAO患者更有可能因房颤/心律不齐而再次入院。进行了各种干预。在发生RAO之后不久，AIS风险最高，强调了紧急，彻底的神经血管评估的重要性。