Composite materials aimed at bone tissue engineering need to have suitable bioactivity in order to promote cell proliferation and adhesion. In this article, we study the potential of boronic acids to improve the bioactivity of chitosan-based composite materials. Samples were prepared using boronic acid functionalised chitosan and Bioglass 45S5. These composite materials, prepared by freeze-drying, exhibit 3D interconnected porosity. The materials were fully characterized using scanning electron microscopy (SEM), FT-IR and x-ray diffraction. Their bioactivity was assessed by immersion in simulated body fluid and cell cytotoxicity assays. Composite materials containing boronic acid show no toxicity for Mouse Sertoli (TM4), Human embryonic kidney 293 (Hek293) and Human bone marrow/stroma (HS-5) cells, as opposed to composites containing non-functionalised chitosan.

针对骨组织工程的复合材料需要具有合适的生物活性，以促进细胞增殖和粘附。在本文中，我们研究了硼酸改善壳聚糖基复合材料生物活性的潜力。使用硼酸官能化的壳聚糖和Bioglass 45S5制备样品。通过冷冻干燥制备的这些复合材料具有3D互连孔隙率。使用扫描电子显微镜（SEM），FT-IR和X射线衍射对材料进行了充分表征。通过浸入模拟体液和细胞毒性实验评估其生物活性。含硼酸的复合材料对小鼠Sertoli（TM4），人胚肾293（Hek293）和人骨髓/基质（HS-5）细胞无毒性，