Background

Although there have been revolutionary improvements in care of IBD patients, considering the effect of lifelong disease with numerous relapses, one of our goals is to recognise burden of chronic symptoms such as fatigue which can significantly interfere with performance of everyday activities, and negatively impact on quality of life (QoL).

Methods

Randomly selected IBD patients were invited to anonymously fulfil multiple mixed-methods (quantitave/qualitative) Quality of Life questionnaires (SF-36, IMPACT, SIDBQ, IBD disk) in order to evaluate prevalence of fatigue as well as the variables associated with an increased risk of fatigue (using the Fisher’s exact test).

Results

The study population included 70 patients (50.7% male, mean age 38.1 years, 55.7% Crohn’s disease). The prevalence of fatigue was 48.6% and variables associated with an increased risk of fatigue were: anxiety/depression (p = 0.002), lower perception of general well-being (p = 0.03), sleep disturbance (p = 0.02), inadequate interpersonal interactions (p = 0.03) and unsatisfactory performance in educational and professional daily activities (p = 0.01). The presence of joint pain as a common extraintestinal manifestation of IBD was not associated with fatigue (p = 0.06).

Conclusion

Chronic fatigue is a debilitating symptom among adult patients with IBD. Anxiety/depression, lower perception of general well-being, sleep disturbance, inadequate interpersonal interactions and unsatisfactory performance in educational and professional daily activities were associated with fatigue in this Croatian cohort of IBD patients.

中文翻译：

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P765疲劳是成年炎症性肠病患者最重要的症状之一：克罗地亚三级中心飞行员研究

背景

尽管IBD患者的护理有了革命性的改善，但考虑到终身疾病伴随多次复发的影响，我们的目标之一是认识到慢性症状（例如疲劳）的负担，这些负担会严重干扰日常活动的进行，并给运动带来负面影响生活质量（QoL）。

方法

邀请随机选择的IBD患者匿名填写多种混合方法（定量/定性）生活质量问卷（SF-36，IMPACT，SIDBQ，IBD磁盘），以评估疲劳的患病率以及与疾病增加相关的变量疲劳风险（使用Fisher精确检验）。

结果

研究人群包括70名患者（男性50.7％，平均年龄38.1岁，克罗恩氏病55.7％）。疲劳患病率为48.6％，与疲劳风险增加相关的变量有：焦虑/抑郁（p = 0.002），总体幸福感较低（p = 0.03），睡眠障碍（p = 0.02），人际关系不足互动（p = 0.03）和在教育和专业日常活动中的表现不理想（p = 0.01）。作为IBD常见的肠外表现的关节痛的存在与疲劳无关（p = 0.06）。

结论

在成年IBD患者中，慢性疲劳是使人衰弱的症状。在这个克罗地亚IBD患者队列中，焦虑/抑郁，对整体健康的较低感知，睡眠障碍，人际交往不足以及在教育和专业日常活动中的不满意表现与疲劳有关。