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P363 Moderate endurance and muscle training are safe to perform for patients with quiescent or mild active Crohn’s disease and increases their strength
Journal of Crohn's and Colitis ( IF 8 ) Pub Date : 2020-01-15 , DOI: 10.1093/ecco-jcc/jjz203.492
W A Seeger 1, 2 , J Thieringer 1 , P Esters 1 , B Allmendinger 1 , H Schulze 1 , A Dignass 1
Affiliation  

Background
The aim of this study was to examine the practicability and potential influence of moderate endurance and muscle training in patients with quiescent or mildly active Crohn’s disease (CD).
Methods
In this randomised controlled pilot trial 45 CD Patients with a CDAI below 220 were randomised to a control, an endurance or a muscle training group. Participants had to exercise individually for 3 months three times per week. Outcome parameters included disease activity (CDAI), inflammatory parameters and calprotectin, anthropometric data, general well-being (sIBDQ), physical activity (IPAQ), cardiorespiratory fitness as well as strength in the upper and lower extremities.
Results
Forty-five patients were randomised into an endurance (17), muscle (15) and control (13) group, respectively. In the endurance group, the dropout rate was 47% (8) vs. 13% (2) in the muscle group and 0 in the control group. Only one patient discontinued the study due to CD specific symptoms. One patient had to stop the study due to another concomitant disease. One patient in each intervention group was lost to follow-up. The most frequent reason for termination was lack of time and motivation: 37.5% (3) in the endurance group vs. 50% (1) in the muscle group. In both groups, the maximal and average force in the upper and lower extremity increased significantly (all p < 0.04). A statistically significant improvement of the quality of life could only be seen in the endurance group in the subclass ‘mood’ of the sIBDQ (p = 0.03). CDAI decreased in the muscle group in contrast to both other groups, statistical significance, however, was not reached.
Conclusion
This study shows that both endurance and muscle training can be safely performed in patients with mild-to-moderate CD. Muscle training seems to be more feasible for this patient group. Both forms of exercise have beneficial effects on strength and presumably on comorbidities, e.g. bone mineral density and thromboembolic complications. Further research in a larger population and also patients with higher disease activity is needed to examine the effects of moderate exercise on disease activity and immunological changes in CD patients.


中文翻译:

P363静止或轻度活动性克罗恩病患者的中等耐力和肌肉训练可以安全地进行,并增加他们的力量

背景
这项研究的目的是检查中度耐力和肌肉训练对患有静止或轻度活动的克罗恩病(CD)患者的实用性和潜在影响。
方法
在这项随机对照的试验性试验中,将45名CDAI低于220的CD患者随机分为对照组,耐力组或肌肉训练组。参加者每周必须进行3个月的独立运动,为期3个月。结果参数包括疾病活动性(CDAI),炎性参数和钙卫蛋白,人体测量数据,一般健康状况(sIBDQ),身体活动(IPAQ),心肺健康状况以及上下肢力量。
结果
四十五名患者分别被分为耐力组(17),肌肉(15)和对照组(13)。在耐力组中,辍学率为47%(8),而肌肉组为13%(2),对照组为0。由于CD特异性症状,只有一名患者中止研究。一名患者由于另一种伴随疾病不得不停止研究。每个干预组中有一名患者失访。终止的最常见原因是缺乏时间和动力:耐力组为37.5%(3),而肌肉组为50%(1)。在两组中,上肢和下肢的最大力和平均力均显着增加(所有p <0.04)。只有在sIBDQ的“情绪”子类别的耐力组中才能看到生活质量的统计上显着改善(p = 0.03)。
结论
这项研究表明,轻度至中度CD患者可以安全地进行耐力和肌肉训练。对于该患者组,肌肉训练似乎更可行。两种形式的运动都对力量和可能对合并症(例如骨矿物质密度和血栓栓塞并发症)产生有益的影响。需要在更大的人群中以及具有更高疾病活动性的患者中进行进一步研究,以检查适度运动对CD患者疾病活动性和免疫学变化的影响。
更新日期:2020-01-17
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