Thin-film evaporator (TFE) is a popular continuous distillation/evaporation technology for pharmaceutical and fine chemical industries and has several equipment and process configurations that make fundamental modeling approaches very challenging. Specifically, moving wipers and lack of fluid dynamics and intraphase and interphase mixing knowledge contribute to the difficulty of developing predictive models. In this article, we present a novel, simple, and practical TFE model developed for active pharmaceutical ingredient continuous manufacturing. The model couples thermodynamic and countercurrent N-continuously stirred tank reactor models and is capable of predicting the TFE performance using various process parameters as inputs. The model’s expanded usage is detailed for the case where the distillate-to-feed ratio was used to control the TFE.

中文翻译：

---

用于连续活性药物成分制造的薄膜蒸发器模型

薄膜蒸发器（TFE）是制药和精细化工行业常用的连续蒸馏/蒸发技术，它具有多种设备和工艺配置，这使基本的建模方法极具挑战性。特别是，运动刮水器，缺乏流体动力学以及相内和相间混合知识不足，导致难以开发预测模型。在本文中，我们提出了一种用于活性药物成分连续制造的新颖，简单和实用的TFE模型。该模型将热力学和逆流N耦合-连续搅拌釜反应器模型，并能够使用各种工艺参数作为输入来预测TFE性能。对于使用馏出物进料比控制TFE的情况，该模型的扩展用法进行了详细说明。