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Mechanotransduction: Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response (Adv. Funct. Mater. 3/2020)
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2020-01-17 , DOI: 10.1002/adfm.202070013
Jeong In Kim 1 , Tae In Hwang 1, 2 , Jeong Chan Lee 3 , Chan Hee Park 1, 4 , Cheol Sang Kim 1, 4
Affiliation  

In article number 1907330, Chan Hee Park, Cheol Sang Kim, and co‐workers develop tunable topography modulated piezoelectric fibrous scaffolds that can regulate electrical cues and mechanotransduction to predict neural cell response. YAP translocation in cells provide clues to how cells respond to topological gradient structure‐modulated piezoelectric scaffolds. Such pleiotropic regulations could fine‐tune the YAP transcriptional pathway, allowing for the determination of cell fate including neural differentiation.
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中文翻译:

机械换能:调节拓扑梯度结构调制压电支架中的电提示和机械转导,以预测神经细胞反应(Adv。Funct。Mater。3/2020)

Chan Hee Park,Cheol Sang Kim和他的同事们在编号1907330中,开发了可调节的地形调制压电纤维支架,该支架可以调节电信号和机械传导以预测神经细胞反应。细胞中的YAP易位为细胞如何响应拓扑梯度结构调制的压电支架提供了线索。这种多效性法规可以微调YAP转录途径,从而确定包括神经分化在内的细胞命运。
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更新日期:2020-01-17
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