Secretory and transmembrane protein synthesis and initial modification are essential processes in protein maturation, and these processes are important for maintaining protein homeostasis in the endoplasmic reticulum (ER). ER homeostasis can be disrupted by the accumulation of misfolded proteins, resulting in ER stress, due to specific intra- or extracellular stresses. Processes including the unfolded protein response (UPR), ER-associated degradation (ERAD) and autophagy are thought to play important roles in restoring ER homeostasis. Here, we focus on summarizing and analysing recent advances in our understanding of the role of ERAD in plant physiological processes, especially in plant adaption to biotic and abiotic stresses, and also identify several issues that still need to be resolved in this field.

中文翻译：

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对植物内质网相关降解的见解。

分泌和跨膜蛋白的合成和初始修饰是蛋白成熟的重要过程，这些过程对于维持内质网（ER）的蛋白稳态非常重要。由于特定的细胞内或细胞外应激，错误折叠的蛋白质的积累会破坏ER稳态，从而导致ER应激。包括未折叠的蛋白质反应（UPR），与ER相关的降解（ERAD）和自噬在内的过程被认为在恢复ER稳态中起重要作用。在这里，我们专注于总结和分析对ERAD在植物生理过程中的作用的理解，特别是在植物适应生物和非生物胁迫方面的最新进展，并且还确定了该领域中仍需解决的几个问题。