The purpose of the study is to propose choroidal spatial distribution indexes (CSDIs) to represent choroidal topographic features, establish a normative database for CSDIs, and identify factors associated with CSDIs in healthy eyes. Retrospective data analysis of 363 healthy eyes from a single-center, prospective, cross-sectional, non-interventional study. Subjects were evaluated using spectral domain OCT with enhanced depth imaging. Choroidal volume and average thickness were measured with OCT in nine macular subfields defined by the Early Treatment Diabetic Retinopathy Study. Vertical CSDI was defined as the natural logarithm of superior choroidal volume divided by inferior choroidal volume. Horizontal CSDI was defined as the natural logarithm of temporal choroidal volume divided by nasal choroidal volume. The overall distributions of vertical and horizontal CSDIs was analyzed. Linear regression analyses were used to identify ocular and systemic factors associated with vertical and horizontal CSDIs. The average vertical CSDI was 0.062 ± 0.206, and average horizontal CSDI was 0.138 ± 0.226. Both vertical and horizontal CSDIs followed normal distribution. Increasing age was significantly associated with greater vertical CSDI (choroidal volume distribution tilted toward the superior region), and longer axial length and thinner subfoveal choroidal thickness were significantly associated with greater horizontal CSDI (choroidal volume distribution tilted toward the temporal region).

中文翻译：

---

脉络膜空间分布指数是脉络膜地形特征的新参数。

这项研究的目的是提出脉络膜空间分布指数（CSDI）来表示脉络膜地形特征，建立CSDI的规范数据库，并确定与健康眼中CSDI相关的因素。来自单中心，前瞻性，横断面，非干预性研究的363例健康眼睛的回顾性数据分析。使用具有增强深度成像的光谱域OCT评估受试者。在早期糖尿病性视网膜病变研究中定义的9个黄斑区中，使用OCT测量脉络膜体积和平均厚度。垂直CSDI定义为上脉络膜体积的自然对数除以下脉络膜体积。水平CSDI定义为颞脉络膜体积的自然对数除以鼻脉络膜体积。分析了垂直和水平CSDI的总体分布。线性回归分析用于确定与垂直和水平CSDI相关的眼和全身因素。平均垂直CSDI为0.062±0.206，平均水平CSDI为0.138±0.226。垂直和水平CSDI都遵循正态分布。年龄的增加与更大的垂直CSDI（脉络膜体积分布向上侧区域倾斜）显着相关，而更长的轴向长度和更小的中央凹脉络膜厚度与更大的水平CSDI（脉络膜体积分布向颞侧区域倾斜）显着相关。平均垂直CSDI为0.062±0.206，平均水平CSDI为0.138±0.226。垂直和水平CSDI都遵循正态分布。年龄的增长与更大的垂直CSDI（脉络膜体积分布向上侧区域倾斜）显着相关，而更长的轴向长度和更小的中央凹脉络膜厚度与更大的水平CSDI（脉络膜体积分布向颞侧区域倾斜）显着相关。平均垂直CSDI为0.062±0.206，平均水平CSDI为0.138±0.226。垂直和水平CSDI都遵循正态分布。年龄的增长与更大的垂直CSDI（脉络膜体积分布向上侧区域倾斜）显着相关，而更长的轴向长度和更小的中央凹脉络膜厚度与更大的水平CSDI（脉络膜体积分布向颞侧区域倾斜）显着相关。