Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a free radical analyzer to measure BAP, and an ocular response analyzer to measure CH and corneal resistance factor (CRF). We evaluated the relationship between systemic oxidative stress and other clinical parameters with Spearman's rank correlation test and a multi-regression analysis. BAP was not correlated to either CH or CRF in the male or female OAG patients. BAP was correlated to both CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 years. Multiple regression analysis revealed that BAP independently contributed to CH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic oxidative stress may significantly affect the viscoelasticity of the cornea in older female OAG patients. Future studies are needed to confirm that low systemic antioxidative status and low corneal hysteresis contribute to glaucoma pathogenesis.

中文翻译：

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青光眼患者氧化应激与角膜滞后的关系。

全身性抗氧化状态与青光眼发病有关。此外，角膜滞后（CH）可能有助于青光眼的进展。在这里，我们评估了生物抗氧化剂潜力（BAP）和CH之间的关系。这项研究包括103例开角型青光眼（OAG）患者。我们使用自由基分析仪测量BAP，并使用眼反应分析仪测量CH和角膜抵抗因子（CRF）。我们通过Spearman秩相关检验和多元回归分析评估了系统性氧化应激与其他临床参数之间的关系。在男性或女性OAG患者中，BAP与CH或CRF均无关。在57岁以上的女性OAG患者中，BAP与CH和CRF相关（r = 0.51，P = 0.003； r = 0.49，P = 0.004），但在57岁以下的女性OAG患者中不相关。多元回归分析显示，在老年OAG女性患者中，BAP独立地导致CH（P = 0.025）和CRF（P = 0.015）。在老年OAG女性患者中，全身性氧化应激可能会严重影响角膜的粘弹性。需要进一步的研究来确认低的全身抗氧化状态和低的角膜滞后作用是青光眼发病的原因。