BACKGROUND Abstinence is a widely-used endpoint in clinical trials of stimulant use disorders. A quantitative measure of frequency of use may be a more sensitive endpoint; however, it is important to establish that it is associated with post-treatment drug use. We examine and compare how within-treatment abstinence and frequency of use are related to two post-treatment longitudinal measures of drug use. METHODS For each of three existing stimulant use disorder clinical trial datasets, we examined the association between within-treatment frequency of use (based on urine screens), within-treatment abstinence, and post-treatment follow-up assessments of drug use (urine screens and reported days of use). In joint analyses that simultaneously model the effects of within-treatment abstinence and frequency of use, it is possible to discern their relative importance as predictors of post-treatment drug use during the 12 months following the end of treatment. RESULTS Results indicate a quantitative measure of within-treatment frequency of use was associated with longitudinal post-treatment follow-up assessments of drug use. Results from joint analyses of post-treatment follow-up drug use assessed by urine screens suggest that within-treatment frequency of use, rather than abstinence per se, is predictive of post-treatment drug use. However, results from joint analyses of self-report of days of use are equivocal. CONCLUSION Results lend support to the use of a quantitative measure of within-treatment drug use as an alternative to complete abstinence. They suggest that some within-treatment use that fall short of complete abstinence may potentially represent clinically important improvements given their association with post-treatment drug use.

中文翻译：

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治疗内使用频率与禁欲作为药物治疗纵向纵向随访评估的预测指标。

背景技术节欲是兴奋剂使用障碍的临床试验中广泛使用的终点。定量使用频率可能是更敏感的终点；但是，重要的是要确定它与治疗后的药物使用有关。我们检查并比较治疗内禁欲和使用频率与治疗后两个纵向药物使用量之间的关系。方法对于三个现有的兴奋剂使用障碍临床试验数据集，我们检查了治疗内使用频率（基于尿液筛查），治疗内禁欲和药物使用后治疗后评估（尿液筛查）之间的关联并报告使用天数）。在同时分析治疗禁欲和使用频率的联合分析中，有可能辨别出它们作为治疗结束后12个月内治疗后药物使用的预测指标的相对重要性。结果结果表明治疗内使用频率的定量测量与药物使用的纵向治疗后随访评估有关。通过尿液筛查评估的治疗后随访药物使用的联合分析结果表明，治疗内使用频率而不是戒酒本身可以预测治疗后的药物使用。但是，联合分析使用天数自我报告的结果是模棱两可的。结论结果支持治疗中药物使用的定量测量作为完全禁欲的替代方法。