Methamphetamine (MA), a psychoactive substance with many medicinal applications in different countries, has destructive impacts on the nervous system and brain and can lead to addiction. The optimal system for MA determination must be able to measure the tiny amount of MA in complex matrixes accurately. In the current work, a simple and biocompatible sensitive optical probe was developed based on molecularly imprinted polymers (MIPs) technique and by using green CQDs and mesoporous structured imprinting microspheres (SiO2@CQDs@ms-MIPs). CQDs (ФF = 33%) were synthesized via the hydrothermal method using natural chewing gum as carbon source. SiO2 nanoparticles were used as the backup substrate for the placement of CQDs. In spite of biocompatibility, porosity and having high specific area are the unique features of SiO2 nanoparticles. When MA is present, the fluorescence response of MIPs enhances. This is caused by the passivation and adjustment of active clusters that are present on the surface of CQDs. By this optical sensor, the favorable linear dynamic range (5.0-250 μM) and the detection limit (1.6 μM) were obtained. The applicability of the advanced sensor was studied in real samples such as human urine and human blood plasma. Acceptable results were obtained and recovery amounts were in the 92-110% interval.

中文翻译：

---

基于介孔结构和绿色纳米颗粒的敏感印迹光学传感器，用于检测血浆和尿液中的甲基苯丙胺。

甲基苯丙胺（MA）是一种精神活性物质，在不同的国家/地区具有许多医学应用，会对神经系统和大脑产生破坏性影响，并可能导致成瘾。用于确定MA的最佳系统必须能够准确地测量复杂矩阵中的微量MA。在当前的工作中，基于分子印迹聚合物（MIPs）技术并使用绿色CQD和介孔结构的印迹微球（SiO2 @ CQDs @ ms-MIPs），开发了一种简单且生物相容的灵敏光学探针。以天然口香糖为碳源，通过水热法合成了CQDs（ФF= 33％）。SiO2纳米颗粒用作放置CQD的备用衬底。尽管具有生物相容性，但多孔性和高比表面积是SiO2纳米颗粒的独特特征。当存在MA时，MIP的荧光反应增强。这是由于CQD表面上存在的活动簇的钝化和调整引起的。通过该光学传感器，获得了良好的线性动态范围（5.0-250μM）和检测极限（1.6μM）。在真实样品（例如人尿和人血浆）中研究了高级传感器的适用性。获得了可接受的结果，回收率在92-110％之间。在真实样品（例如人尿和人血浆）中研究了高级传感器的适用性。获得了可接受的结果，回收率在92-110％之间。在真实样品（例如人尿和人血浆）中研究了高级传感器的适用性。获得了可接受的结果，回收率在92-110％之间。