当前位置: X-MOL 学术NeuroImage › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Four-dimensional map of direct effective connectivity from posterior visual areas
NeuroImage ( IF 5.7 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.neuroimage.2020.116548
Ayaka Sugiura 1 , Brian H Silverstein 2 , Jeong-Won Jeong 3 , Yasuo Nakai 4 , Masaki Sonoda 1 , Hirotaka Motoi 1 , Eishi Asano 3
Affiliation  

Lower- and higher-order visual cortices in the posterior brain, ranging from the medial- and lateral-occipital to fusiform regions, are suggested to support visual object recognition, whereas the frontal eye field (FEF) plays a role in saccadic eye movements which optimize visual processing. Previous studies using electrophysiology and functional MRI techniques have reported that tasks requiring visual object recognition elicited cortical activation sequentially in the aforementioned posterior visual regions and FEFs. The present study aims to provide unique evidence of direct effective connectivity outgoing from the posterior visual regions by measuring the early component (10-50 ms) of cortico-cortical spectral responses (CCSRs) elicited by weak single-pulse direct cortical electrical stimulation. We studied 22 patients who underwent extraoperative intracranial EEG recording for clinical localization of seizure foci and functionally-important brain regions. We used animations to visualize the spatiotemporal dynamics of gamma band CCSRs elicited by stimulation of three different posterior visual regions. We quantified the strength of CCSR-defined effective connectivity between the lower- and higher-order posterior visual regions as well as from the posterior visual regions to the FEFs. We found that effective connectivity within the posterior visual regions was larger in the feedforward (i.e., lower-to higher-order) direction compared to the opposite direction. Specifically, connectivity from the medial-occipital region was largest to the lateral-occipital region, whereas that from the lateral-occipital region was largest to the fusiform region. Among the posterior visual regions, connectivity to the FEF was largest from the lateral-occipital region and the mean peak latency of CCSR propagation from the lateral-occipital region to FEF was 26 ms. Our invasive study of the human brain using a stimulation-based intervention supports the model that the posterior visual regions have direct cortico-cortical connectivity pathways in which neural activity is transferred preferentially from the lower-to higher-order areas. The human brain has direct cortico-cortical connectivity allowing a rapid transfer of neural activity from the lateral-occipital region to the FEF.

中文翻译:

后视区直接有效连接的四维图

后脑中的低阶和高阶视觉皮层,从内侧和外侧枕叶到梭状区域,被建议支持视觉物体识别,而额叶眼场 (FEF) 在扫视眼球运动中起作用优化视觉处理。先前使用电生理学和功能性 MRI 技术的研究报告称,需要视觉对象识别的任务会在上述后部视觉区域和 FEF 中依次引发皮层激活。本研究旨在通过测量弱单脉冲直接皮层电刺激引起的皮质-皮质光谱反应 (CCSR) 的早期成分 (10-50 毫秒),提供从后视觉区域传出的直接有效连接的独特证据。我们研究了 22 名接受术外颅内 EEG 记录的患者,用于临床定位癫痫灶和具有重要功能的大脑区域。我们使用动画来可视化通过刺激三个不同的后部视觉区域引起的伽马波段 CCSR 的时空动态。我们量化了 CCSR 定义的低阶和高阶后视区域之间以及从后视区域到 FEF 的有效连接的强度。我们发现与相反方向相比,后视区域内的有效连接在前馈(即从低阶到高阶)方向上更大。具体来说,从内侧枕区到外侧枕区的连通性最大,而从外侧枕骨区域到梭状区域最大。在后部视觉区域中,从外侧枕部区域到 FEF 的连接性最大,从外侧枕部区域到 FEF 的 CCSR 传播的平均峰值潜伏期为 26 毫秒。我们使用基于刺激的干预对人脑进行的侵入性研究支持后部视觉区域具有直接的皮质 - 皮质连接通路的模型,其中神经活动优先从低阶区域转移到高阶区域。人脑具有直接的皮质 - 皮质连接,允许神经活动从外侧枕区快速转移到 FEF。从枕外侧区到 FEF 的连接最大,从外侧枕区到 FEF 的 CCSR 传播的平均峰值延迟为 26 毫秒。我们使用基于刺激的干预对人脑进行的侵入性研究支持后部视觉区域具有直接的皮质 - 皮质连接通路的模型,其中神经活动优先从低阶区域转移到高阶区域。人脑具有直接的皮质 - 皮质连接,允许神经活动从外侧枕区快速转移到 FEF。从枕外侧区到 FEF 的连接最大,从外侧枕区到 FEF 的 CCSR 传播的平均峰值延迟为 26 毫秒。我们使用基于刺激的干预对人脑进行的侵入性研究支持后部视觉区域具有直接的皮质 - 皮质连接通路的模型,其中神经活动优先从低阶区域转移到高阶区域。人脑具有直接的皮质 - 皮质连接,允许神经活动从外侧枕区快速转移到 FEF。我们使用基于刺激的干预对人脑进行的侵入性研究支持后部视觉区域具有直接的皮质 - 皮质连接通路的模型,其中神经活动优先从低阶区域转移到高阶区域。人脑具有直接的皮质 - 皮质连接,允许神经活动从外侧枕区快速转移到 FEF。我们使用基于刺激的干预对人脑进行的侵入性研究支持后部视觉区域具有直接的皮质 - 皮质连接通路的模型,其中神经活动优先从低阶区域转移到高阶区域。人脑具有直接的皮质 - 皮质连接,允许神经活动从外侧枕区快速转移到 FEF。
更新日期:2020-04-01
down
wechat
bug