Circulating ceramide ratios and risk of vascular brain aging and dementia.,Annals of Clinical and Translational Neurology

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Circulating ceramide ratios and risk of vascular brain aging and dementia.
Annals of Clinical and Translational Neurology ( IF 5.3 ) Pub Date : 2020-01-16 , DOI: 10.1002/acn3.50973
Emer R McGrath _{1,

2,

3} , Jayandra J Himali _{3,

4,

5,

6} , Vanessa Xanthakis _{3,

4,

5} , Meredith S Duncan ₇ , Jean E Schaffer ₈ , Daniel S Ory ₈ , Linda R Peterson ₈ , Charles DeCarli ₉ , Matthew P Pase _{3,

10,

11} , Claudia L Satizabal _{3,

6} , Ramachandran S Vasan _{3,

5} , Alexa S Beiser _{3,

4,

5} , Sudha Seshadri _{3,

5,

6}

Affiliation

Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
Framingham Heart Study, Framingham, Massachusetts.
School of Public Health, Boston University, Boston, Massachusetts.
Boston University School of Medicine, Boston, Massachusetts.
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, Texas.
Vanderbilt University Medical Center, Nashville, Tennessee.
Washington University School of Medicine, St Louis, Missouri.
Department of Neurology, University of California, Davis, California.
Melbourne Dementia Research Centre, The Florey Institute for Neuroscience and Mental Health, Victoria, Australia.
The University of Melbourne, Victoria, Australia.

We determined the association between ratios of plasma ceramide species of differing fatty‐acyl chain lengths and incident dementia and Alzheimer’s disease (AD) dementia in a large, community‐based sample.

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