In this study, we evaluated the effects of anacardic acid (AA), a phenolic lipid found in cashew nuts (Anacardium occidentale), on metabolic disorders related to obesity, fatty liver disease, and diabetes using both in vitro and in vivo models. The application of AA led to a reduction in lipid accumulation in 3T3‐L1 cells without observable cytotoxicity. Results from Western blot analysis revealed that AA treatment also led to decreased expression of fatty acid synthase and peroxisome proliferator‐activated receptor gamma. In vivo studies were performed to evaluate the effects of AA treatment on fatty liver disease and diabetes. Mice fed a high‐fat and high‐sucrose diet had significantly higher body and liver weights, and higher levels of liver fat, cholesterol, fasting glucose, and homeostasis model assessment of insulin resistance (HOMA‐IR). However, 12 weeks of oral treatment with 500 μg/kg BW AA slowed down lipid accumulation rates in the liver and mitigated insulin resistance in these mice. Thus, AA may reduce lipid levels and have an antidiabetic effect.

中文翻译：

---

在食用高脂和高蔗糖饮食的小鼠中，无心果酸可减轻肝脏脂肪的积累和葡萄糖耐量的降低

在这项研究中，我们评估漆树酸（AA）的影响，酚醛脂质腰果发现（腰果），使用体内和体外模型研究与肥胖，脂肪肝和糖尿病相关的代谢异常。AA的应用导致3T3-L1细胞中脂质蓄积减少，而没有可观察到的细胞毒性。Western印迹分析的结果表明，AA处理还导致脂肪酸合酶和过氧化物酶体增殖物激活的受体γ的表达降低。进行了体内研究以评估AA治疗对脂肪肝疾病和糖尿病的影响。饲喂高脂高蔗糖饮食的小鼠的体重和肝重明显较高，并且肝脂肪，胆固醇，空腹血糖和胰岛素抵抗的稳态模型评估（HOMA-IR）较高。然而，用500μg/ kg BW AA口服治疗12周可减缓这些小鼠肝脏中脂质的蓄积速率并减轻胰岛素抵抗。因此，AA可降低脂质水平并具有抗糖尿病作用。