Antifungal natural products : The biosynthesis of the diazeniumdiolate natural product (−)‐fragin was investigated. Feeding experiments suggested valine as the initial substrate. It was also suggested that the biosynthesis of the diazeniumdiolate occurred at an early stage. In a SAR study, derivatives showing variation in the amino acid moiety, the acyl side chain or the diazeniumdiolate displayed reduced activity.

中文翻译：

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二氮杂二氮卓类抗真菌剂Fragin的生物合成与构效关系研究。

抗真菌天然产物：研究了二醇二氮烯鎓天然产物（-）-fragin的生物合成。饲养实验表明缬氨酸是最初的底物。也有人提出，二醇二氮烯鎓的生物合成是在早期进行的。在SAR研究中，衍生物显示出氨基酸部分，酰基侧链或二醇二氮烯鎓盐的变异，其活性降低。