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Expanding the Degradable Proteome: Designing PROTACs by the Book.
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.chembiol.2019.12.009
Martin G Jaeger 1 , Georg E Winter 1
Affiliation  

In this issue of Cell Chemical Biology, Li et al. (2020), Hsu et al. (2020), and Potjewyd et al. (2020) expand the target spectrum amenable to protein degradation by designing degraders of the cell cycle checkpoint kinase Wee1 and the polycomb repressive complex 2 (PRC2) via its regulatory EED subunit.

中文翻译:

扩展可降解蛋白质组:按书设计PROTAC。

Li等在本期《细胞化学生物学》中。(2020),Hsu等。(2020),以及Potjewyd等。(2020)通过设计细胞周期检查点激酶Wee1和多梳抑制复合物2(PRC2)的降解物,通过其调控的EED亚基,扩展了适合蛋白质降解的目标光谱。
更新日期:2020-01-16
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