Cancer immunotherapies, including checkpoint inhibitors and adoptive cell therapy, manipulate the immune system to recognize and attack cancer cells. These therapies have the potential to induce durable responses in multiple solid and hematologic malignancies and thus have transformed treatment algorithms for numerous tumor types. Cancer immunotherapies lead to unique toxicity profiles distinct from the toxicities of other cancer therapies, depending on their mechanism of action. These toxicities often require specific management, which can include steroids and immune‐modulating therapy and for which consensus guidelines have been published. This review will focus on the toxicities of checkpoint inhibitors and chimeric antigen receptor T cells, including pathophysiology, diagnosis, and management.

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癌症免疫治疗毒性综述

癌症免疫疗法，包括检查点抑制剂和过继细胞疗法，操纵免疫系统来识别和攻击癌细胞。这些疗法有可能在多种实体和血液恶性肿瘤中诱导持久反应，从而改变了许多肿瘤类型的治疗算法。癌症免疫疗法导致独特的毒性特征，这与其他癌症疗法的毒性不同，这取决于它们的作用机制。这些毒性通常需要特定的管理，包括类固醇和免疫调节治疗，并且已经发布了共识指南。本综述将重点关注检查点抑制剂和嵌合抗原受体 T 细胞的毒性，包括病理生理学、诊断和管理。