当前位置: X-MOL 学术J. Clin. Virol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Demographic, clinical, and virological characteristics of patients with a laboratory-confirmed diagnosis of influenza during three consecutive seasons, 2015/2016-2017/18, in the Islamic Republic of Iran.
Journal of Clinical Virology ( IF 8.8 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.jcv.2020.104281
Alireza Nateghian 1 , Mohammad Mehdi Gouya 2 , Mahmood Nabavi 2 , Hanieh Soltani 1 , Seyed Vahid Mousavi 3 , Elmira Agah 3 , Hosein Erfani 2 , Peiman Parchami 2 , Mohammadnasr Dadras 2 , Joan L Robinson 4
Affiliation  

BACKGROUND There are minimal data on the differences in demographics, clinical presentations and outcomes for patients with different types and sub-types of influenza in the Middle East. OBJECTIVES To use population-based data from Iran to investigate factors associated with unfavorable disease outcome. STUDY DESIGN Clinical data were compiled from the Iranian Ministry of Health for patients of all ages who fulfilled the severe acute respiratory infections (SARI) definition according to World Health Organization criteriatested for any reason and found to have and had laboratory proven influenza September 21, 2015 through March 20, 2018. Pulmonary, cardiac, renal, hematologic and neurologic complications were recorded. Results were compared by type, age, gender and health status. Multivariate analysis was used to analyze risk factors for complications and death. RESULTS Of 11,080 enrolled patients, 10,046 (90.7 %) were inpatients, 2254 (20.4 %) were children, 8403 (75.8 %) had influenza A, 2599 (23.5 %) had influenza B, and 78 (0.7 %) had unidentified types. Fever was less common in older patients (OR 0.99; 95 % CI 0.98-0.99, p < 0.001 and in those with comorbidity (OR 0.87; 95 % CI 0.77-0.97, p = 0.013). Although the rate of complications was lower with A(H1N1) pdm09 influenza than with A(H3N2) infection (12.8 % versus 15.6 %, p = 0.001), the mortality rate was higher (7.0 % versus 3.0 %, p < 0.001). Complications occurred more often during late versus early influenza season (OR 1.22; 95 % CI 1.08-1.37, p = 0.002). Patients with type B influenza (OR 0.85; 95 % CI 0.74-0.98, p = 0.025), or who presented with sore throat (OR 0.74; 95 % CI 0.65-0.84, p < 0.001) were less likely to develop complications. The risk of developing complications was increased in patients who had chronic heart disease (OR 1.51; 95 % CI 1.29-1.76, p < 0.001), chronic pulmonary disease (OR 1.62; 95 % CI 1.37-1.91, p < 0.001), diabetes (OR 1.24; 95 % CI 1.03-1.50, p = 022), or epilepsy (OR 1.55; 95 % CI 1.17-2.05). Older age and male gender increased the risk of death but not of complications. CONCLUSIONS The clinical features, complications and outcomes of influenza vary by age and by viral type and sub-type. Comorbidites appear to be more important than age in predicting complications.

中文翻译:

伊朗伊斯兰共和国连续三个季节(2015 / 2016-2017 / 18)经实验室确认确诊为流感的患者的人口统计学,临床和病毒学特征。

背景技术关于中东地区不同类型和亚型流感患者的人口统计学,临床表现和结果差异的数据很少。目的使用来自伊朗的基于人口的数据来调查与疾病不利结果相关的因素。研究设计根据世界卫生组织的标准,从伊朗卫生部收集了满足严重急性呼吸道感染(SARI)定义的所有年龄段患者的临床数据,这些标准由于任何原因经过测试并被发现并具有实验室证明的流感,2015年9月21日直至2018年3月20日。记录了肺,心,肾,血液和神经系统并发症。将结果按类型,年龄,性别和健康状况进行比较。多变量分析用于分析并发症和死亡的危险因素。结果在1,080名入组患者中,住院患者为10​​,046名(90.7%),儿童为2254名(20.4%),甲型流感为8403名(75.8%),乙型流感为2599名(23.5%),未鉴定类型为78名(0.7%)。发烧在老年患者中较少见(OR 0.99; 95%CI 0.98-0.99,p <0.001和合并症患者(OR 0.87; 95%CI 0.77-0.97,p = 0.013)。 A(H1N1)pdm09流感病毒比A(H3N2)感染(12.8%对15.6%,p = 0.001),死亡率更高(7.0%对3.0%,p <0.001)。晚期和早期并发症的发生频率更高流感季节(OR 1.22; 95%CI 1.08-1.37,p = 0.002)。B型流感患者(OR 0.85; 95%CI 0.74-0.98,p = 0.025),或出现喉咙痛(OR 0.74; 95%CI 0.65-0.84,p <0.001)的人发生并发症的可能性较小。患有慢性心脏病(OR 1.51; 95%CI 1.29-1.76,p <0.001),慢性肺部疾病(OR 1.62; 95%CI 1.37-1.91,p <0.001),糖尿病的患者发生并发症的风险增加(OR 1.24; 95%CI 1.03-1.50,p = 022)或癫痫病(OR 1.55; 95%CI 1.17-2.05)。老年和男性增加了死亡的风险,但没有增加并发症的风险。结论流感的临床特征,并发症和结局随年龄,病毒类型和亚型而异。合并症在预测并发症方面似乎比年龄更重要。患有慢性心脏病(OR 1.51; 95%CI 1.29-1.76,p <0.001),慢性肺部疾病(OR 1.62; 95%CI 1.37-1.91,p <0.001),糖尿病的患者发生并发症的风险增加(OR 1.24; 95%CI 1.03-1.50,p = 022)或癫痫病(OR 1.55; 95%CI 1.17-2.05)。老年和男性增加了死亡的风险,但没有增加并发症的风险。结论流感的临床特征,并发症和结局随年龄,病毒类型和亚型而异。合并症在预测并发症方面似乎比年龄更重要。患有慢性心脏病(OR 1.51; 95%CI 1.29-1.76,p <0.001),慢性肺部疾病(OR 1.62; 95%CI 1.37-1.91,p <0.001),糖尿病的患者发生并发症的风险增加(OR 1.24; 95%CI 1.03-1.50,p = 022)或癫痫病(OR 1.55; 95%CI 1.17-2.05)。老年和男性增加了死亡的风险,但没有增加并发症的风险。结论流感的临床特征,并发症和结局随年龄,病毒类型和亚型而异。合并症在预测并发症方面似乎比年龄更重要。老年和男性增加了死亡的风险,但没有增加并发症的风险。结论流感的临床特征,并发症和结局随年龄,病毒类型和亚型而异。合并症在预测并发症方面似乎比年龄更重要。老年和男性增加了死亡的风险,但没有增加并发症的风险。结论流感的临床特征,并发症和结局随年龄,病毒类型和亚型而异。合并症在预测并发症方面似乎比年龄更重要。
更新日期:2020-01-16
down
wechat
bug