Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory responses in response to pathogens and cellular damage. Active inflammasomes induce the enzymatic activity of caspase-1, resulting in the induction of inflammatory cell death, pyroptosis, and the maturation and secretion of inflammatory cytokines IL-1β and IL-18. Inflammasomes are activated in many inflammatory diseases, including autoinflammatory disorders and arthritis, and inflammasome-specific therapies are under development for the treatment of inflammatory conditions. In this review, we outline the different inflammasome platforms and recent findings contributing to our knowledge about inflammasome biology in health and disease. In particular, we discuss the role of the inflammasome in the pathogenesis of arthritic diseases, including rheumatoid arthritis, gout, ankylosing spondylitis, and juvenile idiopathic arthritis, and the potential of newly developed therapies that specifically target the inflammasome or its products for the treatment of inflammatory diseases.

中文翻译：

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炎性小体促成关节炎中的炎症。

炎症小体是细胞内的多蛋白信号传导平台，可响应病原体和细胞损伤而引发炎症反应。活跃的炎性体诱导caspase-1的酶活性，从而导致炎性细胞死亡，发烧，炎性细胞因子IL-1β和IL-18的成熟和分泌。炎症小体在许多炎症性疾病（包括自身炎症性疾病和关节炎）中被激活，并且针对炎症性疾病的炎症性小体特异性疗法正在开发中。在这篇综述中，我们概述了不同的炎性体平台和最近的发现，这些知识有助于我们了解健康和疾病中的炎性体生物学。特别是，我们讨论了炎性小体在关节炎疾病发病机理中的作用，