Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has emerged as an attractive diagnostic modality allowing broad-range pathogen detection, noninvasive sampling, and earlier diagnosis. However, little is known about its real-world clinical impact as used in routine practice.

中文翻译：

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血浆无细胞DNA超基因组下一代测序对传染病诊断的临床影响：多中心回顾性队列研究

无浆细胞DNA的超基因组下一代测序（mNGS）已经成为一种有吸引力的诊断方式，可进行广泛的病原体检测，无创采样和早期诊断。但是，对于它在常规实践中对现实世界的临床影响知之甚少。