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Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion.
Organic Letters ( IF 5.2 ) Pub Date : 2020-01-16 , DOI: 10.1021/acs.orglett.9b04387
Jurriën W Collet 1, 2 , Bénédicte Morel 2 , Hung-Chien Lin 1 , Thomas R Roose 1 , Pieter Mampuys 1, 2 , Romano V A Orru 1 , Eelco Ruijter 1 , Bert U W Maes 2
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A robust nickel-catalyzed oxidative isocyanide insertion/C-H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i.e., green solvent, air atmosphere, moderate temperature). The broad range of structurally diverse isocyanides and N-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.

中文翻译:

镍(II)催化异氰酸酯插入法合成致密官能化嘧啶尿嘧啶。

已经报道了通过容易获得的N-尿嘧啶-with与提供多取代的嘧啶嘧啶的异氰酸酯的反应而进行的镍催化的氧化异氰化物的牢固插入/ CH胺化。在温和的条件下(即绿色溶剂,空气气氛,中等温度),反应以中等至定量的产率进行。可以耐受的结构多样的异氰化物和N-尿嘧啶-idine的种类繁多,使该方法成为目前对嘧啶嘧啶的现有方法的有趣替代。
更新日期:2020-01-16
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