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Transition-Metal-Free Approach to Polysubstituted Furans.
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2020-01-16 , DOI: 10.1021/acs.joc.9b03006
Changming You 1 , Zhenming Zhang 1 , Yongliang Tu 1 , Hong Tang 1 , Yuanfeng Wang 1 , Da Long 1 , Junfeng Zhao 1, 2
Affiliation  

A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.

中文翻译:

多取代呋喃的无过渡金属方法。

描述了一种通过β-酮化合物与二氯乙烯的碱促进的多米诺反应合成2,3-二取代和2,3,5-三取代的呋喃的便捷方法。这种无过渡金属的方法在操作简单的反应条件下进行,该条件具有容易获得的起始原料,广泛的底物范围和良好的官能团耐受性。
更新日期:2020-01-26
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