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Effects of risperidone monotherapy on the default-mode network in antipsychotic-naïve first-episode schizophrenia: Posteromedial cortex heterogeneity and relationship with the symptom improvements
Schizophrenia Research ( IF 4.5 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.schres.2020.01.001
Xujun Duan 1 , Maolin Hu 2 , Xinyue Huang 1 , Xia Dong 1 , Xiaofen Zong 2 , Changchun He 1 , Jinming Xiao 1 , Jinsong Tang 3 , Xiaogang Chen 3 , Huafu Chen 1
Affiliation  

The default mode network (DMN) has been consistently detected abnormally in schizophrenia. However, the effects of antipsychotics on this network are still under debate, and inconsistent findings may be due to the functional heterogeneity within the DMN, especially in the component regions of the posteromedial cortex (PMC). Here, we conducted a longitudinal research on the resting-state functional connectivity of the PMC subdivisions on 33 treatment-naive first-episode patients with schizophrenia at baseline and after 8 weeks of risperidone treatment through resting-state functional magnetic resonance imaging. At baseline, the patients demonstrated decreased connectivity of the three PMC seeds with several brain regions (target regions) compared with healthy controls. We then tested the effect of antipsychotic treatment on the functional connectivity between the three seeds and the target regions. We found that, one of the three seeds encompassed in PMC, namely, posterior cingulate cortex (PCC), was observed to have increased functional connectivity with the bilateral thalamus and the left lingual gyrus (LG). On the contrary, the functional connectivity between the target regions and the two remaining seeds, namely, the retrosplenial cortex and precuneus, was unaffected by risperidone treatment. Correlation analysis revealed a positive correlation between longitudinal change of PCC-LG connectivity and symptom improvement. These findings indicated the heterogeneity of the PMC in response to antipsychotic treatment and suggested the role of PCC as a treatment biomarker for schizophrenia.

中文翻译:

利培酮单药治疗对初次服用抗精神病药的首发精神分裂症默认模式网络的影响:后内侧皮质异质性及其与症状改善的关系

默认模式网络 (DMN) 在精神分裂症中一直被异常检测到。然而,抗精神病药物对该网络的影响仍在争论中,不一致的发现可能是由于 DMN 内的功能异质性,特别是在后内侧皮层 (PMC) 的组成区域。在这里,我们通过静息态功能磁共振成像对 33 名初治精神分裂症患者在基线和利培酮治疗 8 周后 PMC 细分的静息态功能连通性进行了纵向研究。在基线时,与健康对照相比,患者表现出三个 PMC 种子与几个大脑区域(目标区域)的连接性降低。然后我们测试了抗精神病药物治疗对三个种子和目标区域之间的功能连接的影响。我们发现,PMC 中包含的三个种子之一,即后扣带回皮层 (PCC),被观察到与双侧丘脑和左舌回 (LG) 的功能连接增加。相反,目标区域与剩余的两个种子(即脾后皮质和楔前叶)之间的功能连接不受利培酮处理的影响。相关分析显示 PCC-LG 连接的纵向变化与症状改善之间呈正相关。这些发现表明 PMC 对抗精神病药治疗的异质性,并表明 PCC 作为精神分裂症治疗生物标志物的作用。
更新日期:2020-04-01
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