The manifesto proposed by Roche et al. [1] is a most important plan to revolutionise respiratory clinical research. It also prompts a key question about the balance between the effort spent on randomised clinical trials (RCTs) versus real-life research (RLR), particularly in an era where frequent monitoring of patients capturing their real life, using wearable devices, home diagnostics, smartphones, smart inhalers, collections of contextual information, cloud connectivity and the ability to analyse large complex datasets is becoming increasingly feasible [2]. Real-life clinical research may be more valuable to achieve the aspirations of personalised medicine than the traditional “regulatory style” randomised clinical trials http://bit.ly/2M7vnYT

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我们在临床研究中需要什么样的重点来实现个性化呼吸医学？

罗氏等人提出的宣言。[1] 是彻底改变呼吸临床研究的最重要计划。它还提出了一个关键问题，即在随机临床试验 (RCT) 与现实生活研究 (RLR) 上花费的努力之间的平衡，特别是在一个频繁监测患者真实生活的时代，使用可穿戴设备、家庭诊断、智能手机、智能吸入器、上下文信息集合、云连接以及分析大型复杂数据集的能力变得越来越可行 [2]。现实生活中的临床研究可能比传统的“监管式”随机临床试验对实现个性化医疗的愿望更有价值 http://bit.ly/2M7vnYT