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Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN.
Life Sciences ( IF 6.1 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.lfs.2020.117297
Shifang Sun 1 , Hailin Chen 2 , Chenlei Xu 3 , Yun Zhang 1 , Qiaoli Zhang 1 , Lei Chen 1 , Qunli Ding 1 , Zaichun Deng 1
Affiliation  

As novel non-invasive tumor diagnostic biomarkers, exosomal bioactive miRNAs have received increasing attention. Herein, the aim of this study is to explore the clinical values and roles of exosomal miR106b in lung cancer. The exosomal miR-106b level was much higher in the serum of patients with lung cancer than that in healthy volunteers. Also, the exosomal miR-106b level in the lung cancer patient serum was associated with TNM stages and lymph node metastasis. Furthermore, exosomal miR-106b enhanced the migrated and invasive ability of lung cancer cells and increased the MMP-2 and MMP-9 expression. Mechanistically, exosomal miR-106b could target PTEN, and promote lung cancer cell migration and invasion. More importantly, PTEN overexpression reversed the effect of exosomal miR-106b on lung cancer cell migration and invasion. Taken together, these findings indicate that exosomal miR-106b may be a promising diagnostic biomarker and drug target for patients with lung cancer.

中文翻译:

外泌体miR-106b用作肺癌的新型标志物,并通过靶向PTEN促进癌症转移。

作为新型的非侵入性肿瘤诊断生物标志物,外泌体生物活性miRNA受到越来越多的关注。在此,本研究的目的是探索外泌体miR106b在肺癌中的临床价值和作用。肺癌患者血清中的外泌体miR-106b水平远高于健康志愿者。而且,肺癌患者血清中的外泌体miR-106b水平与TNM分期和淋巴结转移有关。此外,外泌体miR-106b增强了肺癌细胞的迁移和侵袭能力,并增加了MMP-2和MMP-9的表达。从机制上讲,外泌体miR-106b可以靶向PTEN,并促进肺癌细胞的迁移和侵袭。更重要的是,PTEN过表达逆转了外泌体miR-106b对肺癌细胞迁移和侵袭的影响。在一起
更新日期:2020-01-16
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