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Surface modification of silicone elastomer with rosin acid-based quaternary ammonium salt for antimicrobial and biocompatible properties
Materials & Design ( IF 8.4 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.matdes.2020.108493
Zhaoshuang Li , He Liu , Xu Xu , Lina Ma , Shibin Shang , Zhanqian Song

Abstract Despite advanced sterilized and aseptic techniques, biomaterial-associated infections are still posing a great threat to human life. Therefore, constructing antimicrobial coating that exerts potent antimicrobial activity combined with low cytotoxicity is of great significance. Herein, an antimicrobial coating on the surface of silicone elastomer (PDMS) has been successful constructed, which based on maleopimaric acid quaternary ammonium cation (MPA-N+). The surface morphology and chemical composition of modified PDMS (PDMS-g-MPA-N+) were confirmed by scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), and X-ray photoelectron spectroscopy (XPS). The PDMS-g-MPA-N+ possess excellent antimicrobial activity against both Gram-positive bacterial (Staphylococcus aureus) and Gram-negative bacterial (Escherichia coli, Pseudomonas aeruginosa) strains. In addition, confocal laser scanning microscopy imaging demonstrated that it also can effectively inhibit bacterial biofilm formation over 5 days. Most importantly, PDMS-g-MPA-N+ exhibited excellent biocompatibility, which induced no significant hemolysis and cytotoxicity toward mammalian cells. The study demonstrated that the silicone elastomer surface grafted with MPA-N+ enabled the incorporation of a renewable biomass to effectively combat bacteria and biofilm formation for biomedical applications.

中文翻译:

用松香酸基季铵盐对有机硅弹性体进行表面改性以获得抗菌和生物相容性

摘要 尽管采用了先进的灭菌和无菌技术,但生物材料相关感染仍然对人类生命构成巨大威胁。因此,构建具有有效抗菌活性和低细胞毒性的抗菌涂层具有重要意义。在此,成功构建了基于马来海松酸季铵阳离子 (MPA-N+) 的有机硅弹性体 (PDMS) 表面的抗菌涂层。通过扫描电子显微镜 (SEM)、能谱仪 (EDS) 和 X 射线光电子能谱 (XPS) 证实了改性 PDMS (PDMS-g-MPA-N+) 的表面形貌和化学成分。PDMS-g-MPA-N+ 对革兰氏阳性菌(金黄色葡萄球菌)和革兰氏阴性菌(大肠杆菌,铜绿假单胞菌)菌株。此外,共聚焦激光扫描显微镜成像表明,它还可以在 5 天内有效抑制细菌生物膜的形成。最重要的是,PDMS-g-MPA-N+表现出优异的生物相容性,对哺乳动物细胞没有明显的溶血和细胞毒性。该研究表明,接枝有 MPA-N+ 的有机硅弹性体表面能够引入可再生生物质,从而有效地对抗细菌和生物膜形成,用于生物医学应用。
更新日期:2020-04-01
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