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Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-01-15 , DOI: 10.1002/adhm.201901211
Tian Li 1, 2 , Bing Ma 1 , Jianmin Xue 1, 2 , Dong Zhai 1 , Pengyu Zhao 1, 2 , Jiang Chang 1, 2 , Chengtie Wu 1, 2
Affiliation  

The fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity, remains challenging because these properties are usually mutually exclusive. Herein, inspired by the brick-and-mortar architecture of nacre, lamellar silicate-based bioceramic composites are successfully prepared by constructing orderly layered bioceramics infiltrated with a biomedical resin interlayer via the bidirectional freezing technique. The lamellar composites possess high strength and proper Young's moduli, which match with human cortical bone. Furthermore, the lamellar composites can release bioactive ions with a controlled profile, which significantly enhance the cell proliferation of both rabbit bone mesenchymal stem cells and periodontal ligament cells in vitro. Moreover, with the degradation of silicate bioceramics in vivo, newly formed bone tissue can grow into the materials to present the bioceramic/new bone/resin sandwich-like lamellar microstructure. The silicate-based bioceramic composites with brick-and-mortar architecture represent an excellent biomaterial in combination of superior mechanical performances matching that of human cortical bone, and excellent bioactivity for potential load-bearing bone regeneration.

中文翻译:

生物启发的生物材料,具有结合机械和生物性能的砖砂浆微结构。

同时具有优异的机械性能和出色的生物活性的骨再生生物材料的制造仍然具有挑战性,因为这些特性通常是相互排斥的。在此,受珍珠质的砖瓦结构的启发,通过构造通过双向冷冻技术渗透了生物医学树脂夹层的有序层状生物陶瓷,成功地制备了层状硅酸盐基生物陶瓷复合材料。层状复合材料具有高强度和适当的杨氏模量,可与人的皮质骨相匹配。此外,层状复合材料可以释放具有受控分布的生物活性离子,从而显着增强体外兔骨间充质干细胞和牙周膜细胞的细胞增殖。此外,随着体内硅酸盐生物陶瓷的降解,新形成的骨组织可以成长为材料,从而呈现出生物陶瓷/新骨/树脂夹心状层状微结构。具有砖混结构的硅酸盐基生物陶瓷复合材料代表了一种出色的生物材料,其优异的机械性能与人的皮质骨相匹配,并且具有出色的生物活性,可用于潜在的负重骨骼再生。
更新日期:2020-02-19
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