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Incarnolides A and B, Two Schinortriterpenoids with a Tricyclo[9.2.1.02,8]tetradecane-Bridged System from Schisandra incarnata.
Organic Letters ( IF 5.2 ) Pub Date : 2020-01-15 , DOI: 10.1021/acs.orglett.9b04600
Juan Chen 1 , Xiao-Gang Peng 1 , Junjun Liu 1 , Ying Gao 1 , Ming Zhou 1 , Jia Zhou 1 , Jian Song 1 , Han-Li Ruan 1
Affiliation  

Incarnolides A (1) and B (2), two schinortriterpenoids (SNTs) featuring a tricyclo[9.2.1.02,8]tetradecane-bridged system, together with two biosynthetically related known SNTs, lancifonins A (3) and C (4), were isolated from the stems of Schisandra incarnata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute configurations were assigned by single-crystal X-ray diffraction and electronic circular dichroism calculation. The hypothetical biogenetic pathway of 1 and 2 was postulated. Compound 1 exhibited antiviral and neuroprotective activities.

中文翻译:

Incarnolides A和B,两个五味子三萜与Schisandra incarnata的三环[9.2.1.02,8]十四烷桥连系统。

Incarnolides A(1)和B(2),两个以三环[9.2.1.02,8]十四烷桥连系统为特征的Schinortriterpenoids(SNT),以及两个生物合成相关的已知SNT,lancifonins A(3)和C(4),从北五味子的茎中分离出来。通过广泛的光谱分析阐明了它们的结构,并通过单晶X射线衍射和电子圆二色性计算确定了绝对构型。假设了1和2的假设生物发生途径。化合物1表现出抗病毒和神经保护活性。
更新日期:2020-01-15
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