In this paper, we report efficient cyanation of various peptides containing the α-bromocarbonyl moiety using a Cu-catalyzed radical-based methodology employing zinc cyanide as the cyanide source. Mechanistic studies revealed that in situ formed CuCN was a key intermediate during the catalytic cycle. Our method could be useful for the synthesis of modified peptides containing quaternary carbons.

中文翻译：

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铜催化叔烷基化氰化用于合成氰化肽结构单元

在本文中，我们报告了使用氰化锌作为氰化物源的铜催化自由基方法对含有 α-溴羰基部分的各种肽进行有效氰化。机理研究表明，原位形成的 CuCN 是催化循环过程中的关键中间体。我们的方法可用于合成含有季碳的修饰肽。