Drug misuse in prisons contributes to increased disruption and violence and negatively impacts prisoner safety, rehabilitation, and recovery. Synthetic cannabinoid receptor agonists (SCRAs), colloquially known as “spice”, are infused into papers and are of particular concern in a prison setting where they are commonly vaped. Methods for the qualitative and quantitative analysis of SCRA infused papers, including impurity profiling, were developed using gas chromatography–mass spectrometry (GC–MS) with qualitative confirmation by ultra high pressure liquid chromatography with photodiode array and quadrupole time of flight mass spectrometry detection (UPLC‐PDA‐QToF‐MS) and applied to 354 individual seized paper samples originating from 168 seizures from three Scottish prisons. Of these samples, 41% (146 samples from 101 seizures) contained at least one SCRA and multiple SCRAs were detected on 23% of these papers. Concentrations ranged from < 0.05–1.17 mg/cm² paper, representing the first reported quantitative data for SCRA infused papers. An evolution in the SCRAs detected was demonstrated; 5F‐MDMB‐PINACA (5F‐ADB) predominated until late 2018, after which time 5F‐MDMB‐PICA and 4F‐MDMB‐BINACA became increasingly more prevalent, followed by the arrival of MDMB‐4en‐PINACA in June 2019. Concentration mapping data from two seized paper samples demonstrated that SCRA concentrations across larger papers were highly variable (0.47–2.38 mg/cm² paper) making consistent dosing by users, and representative sampling by laboratory analysts, difficult. Near real‐time qualitative and quantitative information on SCRAs circulating in prisons acts as an early warning system for SCRAs emerging on the wider illicit market, inform the methods used to detect them and limit supply, and provide information to support harm reduction measures.

中文翻译：

---

在不断发展的非法市场中，从监狱中注入的文件中检测和定量合成大麻素受体激动剂。

监狱中滥用毒品的行为加剧了破坏和暴力，对囚犯的安全，康复和康复造成了负面影响。俗称“香料”的合成大麻素受体激动剂（SCRA）被注入纸张中，在监狱中通常被抽烟的情况下尤其令人关注。使用气相色谱-质谱法（GC-MS）开发了SCRA注入纸的定性和定量分析方法，包括杂质分布图，并通过具有光电二极管阵列和四极杆飞行时间质谱检测的超高压液相色谱法进行了定性确认（ UPLC-PDA-QToF-MS）并应用于来自三个苏格兰监狱的168次缉获的354个单独的纸张样本。在这些样本中 41％（101个癫痫发作的146个样本）包含至少一种SCRA，在其中23％的论文中检测到多种SCRA。浓度范围<0.05–1.17 mg / cm²篇论文，代表了第一个报告的SCRA灌注论文的定量数据。证实了所检测到的SCRA的演变；5F‐MDMB‐PINACA（5F‐ADB）一直占主导地位，直到2018年底，此后5F‐MDMB‐PICA和4F‐MDMB‐BINACA变得越来越普遍，随后MDMB‐4en‐PINACA于2019年6月到来。浓度图来自两个查获的纸张样本的数据表明，较大纸张上的SCRA浓度变化很大（0.47–2.38 mg / cm ²纸）很难使用户保持一致的剂量，而使实验室分析人员难以进行代表性采样。监狱中流传的SCRA的近乎实时的定性和定量信息，可作为在更广泛的非法市场上出现的SCRA的预警系统，为检测它们和限制供应的方法提供信息，并提供信息以支持减少危害的措施。