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A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria.
Nature Communications ( IF 16.6 ) Pub Date : 2020-01-15 , DOI: 10.1038/s41467-019-14133-x
Bai-Lu Tang 1 , Jie Yang 1 , Xiu-Lan Chen 1 , Peng Wang 1, 2 , Hui-Lin Zhao 1 , Hai-Nan Su 1 , Chun-Yang Li 2, 3 , Yang Yu 1 , Shuai Zhong 1 , Lei Wang 1 , Ian Lidbury 4 , Haitao Ding 5 , Min Wang 2 , Andrew McMinn 2, 6 , Xi-Ying Zhang 1 , Yin Chen 2, 4 , Yu-Zhong Zhang 1, 2, 3
Affiliation  

Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp. strain CF6-2) can kill Gram-positive bacteria of diverse peptidoglycan (PG) chemotypes by secreting the metalloprotease pseudoalterin. Secretion of the enzyme requires a Type II secretion system. Pseudoalterin binds to the glycan strands of Gram positive bacterial PG and degrades the PG peptide chains, leading to cell death. The released nutrients, including PG-derived D-amino acids, can then be utilized by strain CF6-2 for growth. Pseudoalterin synthesis is induced by PG degradation products such as glycine and glycine-rich oligopeptides. Genes encoding putative pseudoalterin-like proteins are found in many other marine bacteria. This study reveals a new microbial interaction in the ocean.

中文翻译:

海洋Pseudoalteromonas sp。之间的捕食者与猎物的相互作用。和革兰氏阳性细菌。

捕食者与猎物之间的相互作用在海洋有机物循环中起重要作用。在这里,我们显示从海洋沉积物中分离的革兰氏阴性细菌(假单孢菌属菌株CF6-2)可以通过分泌金属蛋白酶假alterin杀死多种肽聚糖(PG)化学型的革兰氏阳性细菌。酶的分泌需要II型分泌系统。伪alterin结合革兰氏阳性细菌PG的聚糖链并降解PG肽链,导致细胞死亡。然后释放的营养素,包括PG衍生的D-氨基酸,可被CF6-2菌株用于生长。伪alterin的合成是由PG降解产物(如甘氨酸和富含甘氨酸的寡肽)诱导的。在许多其他海洋细菌中也发现了编码假定的伪alterin-like蛋白的基因。
更新日期:2020-01-15
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