OsH₆(PⁱPr₃)₂ has been used to selectively activate C–H, O–H, and C–C sigma bonds in nucleobases and nucleosides, including derivatives of 6-phenylpurine and 4-phenylpyrimidine, leading to cyclometalated mononuclear Os–trihydride complexes, in excellent yields and as single products. Additionally, OsH₆(PⁱPr₃)₂ promotes the efficient dehydrogenative decarbonylation of primary alcohols in nucleosides having unprotected sugar moieties. The incorporation of OsH₂Cl₂(PⁱPr₃)₂ in the structure of cyclometalated Ir(III) and Rh(III) half-sandwich complexes derived from nucleosides allows the preparation of a class of heterobimetallic bioorganometallic complexes having at least one M–C bond. These methodologies could be used in the future as a way for the orthogonal functionalization of oligonucleotides.

中文翻译：

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Nu在核苷上促进的σ键活化反应

OsH ₆（P ⁱ Pr ₃）₂已被用于选择性激活核碱基和核苷中的C–H，OH–和C–C sigma键，包括6-苯基嘌呤和4-苯基嘧啶的衍生物，从而形成环金属化的单核Os -三氢化物配合物，收率极高，可作为单一产品使用。另外，OsH ₆（P ⁱ Pr ₃）₂促进具有未保护的糖部分的核苷中伯醇的有效脱氢脱羰作用。OsH ₂ Cl ₂（P ⁱ Pr ₃）₂的引入在环金属化的Ir（III）和Rh（III）核苷半夹心络合物的结构中，可以制备一类具有至少一个M-C键的异双金属生物有机金属络合物。这些方法可在将来用作寡核苷酸正交功能化的方法。