The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity and dismal prognosis. We show that acute activation of Myc in indolent PanIN epithelial cells in vivo is, alone, sufficient to trigger immediate release of instructive signals that together coordinate changes in multiple stromal and immune cell types and trigger transition to pancreatic adenocarcinomas that share all the characteristic stromal features of their spontaneous human counterpart. We also demonstrate that this Myc-driven PDAC switch is completely and immediately reversible: Myc deactivation/inhibition triggers meticulous disassembly of advanced PDAC tumor and stroma and concomitant death of tumor cells. Hence, both the formation and deconstruction of the complex PDAC phenotype are continuously dependent on a single, reversible Myc switch.

中文翻译：

---

Myc 指导和维持胰腺腺癌表型。

胰腺导管腺癌 (PDAC) 的标志性特征是其纤维炎性基质、免疫活性差和预后不佳。我们表明，在体内惰性 PanIN 上皮细胞中 Myc 的急性激活，单独地，足以触发指导性信号的立即释放，这些信号共同协调多种基质和免疫细胞类型的变化，并触发向具有所有特征性基质特征的胰腺癌的转变他们自发的人类对应物。我们还证明，这种 Myc 驱动的 PDAC 开关是完全且立即可逆的：Myc 失活/抑制触发晚期 PDAC 肿瘤和基质的精细分解以及肿瘤细胞的伴随死亡。因此，复杂 PDAC 表型的形成和解构都持续依赖于单个、