Gelatin is used in a broad range of tissue engineering applications because of its bioactivity, mild processing conditions, and ease of modification, which have increased interest in its use as a growth factor delivery vehicle. Traditional methods to control growth factor sequestration and delivery have relied on controlling hydrogel mesh size via chemical crosslinking with corollary changes to the physical properties of the hydrogel. To decouple growth factor release from scaffold properties, affinity sequestration modalities have been developed to preserve the bioactivity of the growth factor through interactions with the modified gelatin. This review provides a summary of these mechanisms, highlights current gelatin growth factor delivery systems, and addresses the future perspective of gelatin matrices for growth factor delivery in tissue engineering.

中文翻译：

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用于生长因子隔离的明胶基质。

明胶因其生物活性、温和的加工条件和易于修饰而被广泛用于组织工程应用，这增加了人们对其作为生长因子递送载体的兴趣。控制生长因子封存和递送的传统方法依赖于通过化学交联控制水凝胶网格尺寸，并随之改变水凝胶的物理性质。为了将生长因子的释放与支架特性分离，开发了亲和螯合方式，通过与改性明胶的相互作用来保留生长因子的生物活性。本综述总结了这些机制，重点介绍了当前的明胶生长因子递送系统，并探讨了明胶基质在组织工程中用于生长因子递送的未来前景。