SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1^+/- mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of Syngap1^+/- rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.

中文翻译：

---

啮齿动物对突触后突触后突触后密度的反应中的性别差异

SynGAP是一种突触后密度（PSD）蛋白，与支架蛋白PSD-95的PDZ域结合。我们先前曾报道，小鼠中Syngap1的杂合缺失与结合PSD-95的其他关键PSD蛋白的稳态水平提高相关，尽管PSD-95的水平保持恒定（Walkup et al。，2016）。例如，在年轻的Syngap1 ^+/-小鼠中，介导AMPA型谷氨酸受体与PSD-95结合的跨膜AMPA受体相关蛋白（TARP）与PSD-95的比率增加。在这里，我们显示只有女性而不是男性在Syngap1 ^+/- PSD的TARP增加与synGAP减少之间显示出高度显着的相关性啮齿动物。数据揭示了PSD支架适应synGAP单倍体功能不足的性别差异。