BACKGROUND This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after hepatitis B vaccine was introduced in the national immunization scheduled for children. METHODS In 2018, a community-based, random sampling strategy with probability proportional to population size was conducted in Nanoro to investigate the prevalence of viral hepatitis in children and their mothers. Sociodemographic, vaccination history and risk factors were assessed by interview and health books. HBsAg rapid tests were done by finger prick and Dried Blood Spots (DBS) were collected for hepatitis seromarkers by chemiluminescence enzyme immunoassay. Positive samples underwent confirmatory PCR and phylogenetic analysis. RESULTS Data were presented on 240 mother-child pairs. HBsAg Prevalence was 0.8% in children and 6.3% in mothers. Hepatitis B core antibody positivity was 89.2% in mothers, 59.2% in children and was associated with age, sex and scarification. Hepatitis B surface antibodies prevalence was 37.5% in children and 5.8% in mothers. Good vaccination coverage was limited by home delivery. Phylogenetic analysis of HBV strains based on full genome sequences (n = 7) and s-fragment sequences (n = 6) revealed genotype A, E, and recombinant A3/E. Viral genome homology was reported in one mother-child pair. Anti-HCV prevalence was 5.4% in mothers, 2.1% in children and strains belonged to genotype 2. CONCLUSIONS In Nanoro, HBsAg prevalence was low in children, intermediate in mothers and mother-to-child transmission persists. Home delivery was a limiting factor of Hepatitis B vaccination coverage. HBV genotype E was predominant and genotype A3/E is reported for the first time in Burkina Faso.

中文翻译：

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布基纳法索农村地区Nanoro乙型和丙型肝炎感染的流行病学变化：一项随机抽样调查。

背景技术这项研究试图在为儿童计划的国家免疫接种乙肝疫苗十年后，向布基纳法索农村地区提供最新的乙肝（HBV）和丙肝（HCV）血清阳性率。方法2018年，在Nanoro中进行了一项基于社区的随机抽样策略，其概率与人口规模成正比，以调查儿童及其母亲中病毒性肝炎的患病率。社会人口学，疫苗接种史和危险因素通过访谈和健康书籍进行评估。HBsAg快速检测通过手指点刺进行，并通过化学发光酶免疫测定法收集肝炎血清标志物的干血斑（DBS）。阳性样品经过验证性PCR和系统发育分析。结果数据显示了240对母子对。儿童和6岁儿童的HBsAg患病率为0.8％。母亲中占3％。母亲的乙型肝炎核心抗体阳性率为89.2％，儿童为59.2％，并与年龄，性别和划痕有关。乙型肝炎表面抗体患病率在儿童中为37.5％，在母亲中为5.8％。良好的疫苗接种范围受到送货上门的限制。基于全基因组序列（n = 7）和s片段序列（n = 6）的HBV病毒株的系统发育分析揭示了基因型A，E和重组A3 / E。在一对母子对中报告了病毒基因组同源性。母亲的抗HCV患病率为5.4％，儿童和菌株属于基因型2。结论结论在Nanoro中，儿童的HBsAg患病率较低，在母亲中处于中等水平，并且母婴传播仍然存在。送货上门是乙肝疫苗接种覆盖率的限制因素。