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A systematic review and meta-analysis of the prevalence of hepatitis C virus infection in people who inject drugs in Iran.
BMC Public Health ( IF 4.5 ) Pub Date : 2020-01-14 , DOI: 10.1186/s12889-020-8175-1
Masoud Behzadifar 1 , Meysam Behzadifar 2 , Nicola Luigi Bragazzi 3
Affiliation  

BACKGROUND Hepatitis C virus (HCV) infection is one of the major public health challenges generating a relevant burden. High-risk groups, including people who inject drugs (PWID), are at serious risk for developing HCV. In recent years, several investigations have been conducted in Iran to assess the prevalence e of HCV among PWID. The aim of the present study was to synthesize the literature performing a comprehensive search and meta-analysis. METHODS A comprehensive literature search was carried out from January 2000 to September 2019. Several international databases, namely Scopus, PubMed/MEDLINE, Embase, ISI/Web of Science, PsycINFO, CINAHL, the Cochrane Library and the Directory of Open Access Journals (DOAJ), as well as Iranian databases (Barakathns, SID and MagIran), were consulted. Eligible studies were identified according to the following PECOS (population, exposure, comparison/comparator, outcome and study type) criteria: i) population: Iranian population; ii) exposure: injection drug users; iii) comparison/comparator: type of substance injected and level of substance use, iv) outcome: HCV prevalence; and v) study type: cross-sectional study. After finding potentially related studies, authors extracted relevant data and information based on an ad hoc Excel spreadsheet. Extracted data included the surname of the first author, the study journal, the year of publication, the number of participants examined, the type of diagnostic test performed, the number of positive HCV patients, the number of participants stratified by gender, the reported prevalence, the duration of drug injection practice and the history of using a shared syringe. RESULTS Forty-two studies were included. 15,072 PWID were assessed for determining the prevalence of HCV. The overall prevalence of HCV among PWID in Iran was computed to be 47% (CI 95: 39-56). The prevalence ranged between 7 and 96%. Men and subjects using a common/shared syringe were 1.46 and 3.95 times more likely to be at risk, respectively. CONCLUSION The findings of the present study showed that the prevalence of HCV among PWIDs in Iran is high. The support and implementation of ad hoc health-related policies and programs that reduce this should be put into action.

中文翻译:

对在伊朗注射毒品的人中丙型肝炎病毒感染率的系统评价和荟萃分析。

背景技术丙型肝炎病毒(HCV)感染是产生相关负担的主要公共卫生挑战之一。包括注射毒品(PWID)在内的高风险人群处于发展HCV的严重风险中。近年来,在伊朗进行了几项调查,以评估PWID中HCV的患病率。本研究的目的是合成进行全面搜索和荟萃分析的文献。方法从2000年1月至2019年9月进行了全面的文献检索。一些国际数据库,即Scopus,PubMed / MEDLINE,Embase,ISI / Web of Science,PsycINFO,CINAHL,Cochrane图书馆和开放获取期刊目录(DOAJ) )以及伊朗的数据库(Barakathns,SID和MagIran)进行了咨询。根据以下PECOS(人口,暴露,比较/比较,结果和研究类型)标准确定了合格的研究:i)人口:伊朗人口;ii)接触:注射吸毒者;iii)比较/比较器:注入的物质类型和物质使用水平,iv)结果:HCV患病率;v)研究类型:横断面研究。在找到潜在的相关研究后,作者基于一个临时的Excel电子表格提取了相关的数据和信息。提取的数据包括第一作者的姓氏,研究期刊,出版年份,检查的参与者人数,进行的诊断测试的类型,HCV阳性患者的人数,按性别分层的参与者人数,报告的患病率,药物注射实践的持续时间以及使用共用注射器的历史。结果纳入42项研究。评估了15,072个PWID以确定HCV的患病率。据计算,伊朗PWID中HCV的总体患病率为47%(CI 95:39-56)。患病率在7%至96%之间。使用共同/共用注射器的男性和受试者患病风险的可能性分别为1.46和3.95倍。结论本研究的结果表明,伊朗的PWID中HCV的患病率很高。应当采取支持和执行与卫生相关的特设政策和计划,以减少这种情况。据计算,伊朗PWID中HCV的总体患病率为47%(CI 95:39-56)。患病率在7%至96%之间。使用共同/共用注射器的男性和受试者患病风险的可能性分别为1.46和3.95倍。结论本研究的结果表明,伊朗的PWID中HCV的患病率很高。应当采取支持和执行与卫生相关的特设政策和计划,以减少这种情况。据计算,伊朗PWID中HCV的总体患病率为47%(CI 95:39-56)。患病率在7%至96%之间。使用共同/共用注射器的男性和受试者患病风险的可能性分别为1.46和3.95倍。结论本研究的结果表明,伊朗的PWID中HCV的患病率很高。应当采取支持和执行与卫生相关的特设政策和计划,以减少这种情况。
更新日期:2020-01-15
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