Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to apoptosis and autophagic pathways. The importance of NAD+ in ageing and healthy longevity has been revealed from laboratory animal studies and early-stage clinical testing. While basic researchers and clinicians have investigated the molecular mechanisms and translation potential of NAD+, there are still major gaps in applying laboratory science to design the most effective trials. This mini-review was based on the programme and discussions of the 3rd NO-Age Symposium held at the Akershus University Hospital, Norway on the 28th October 2019. This symposium brought together leading basic researchers on NAD+ and clinicians who are leading or are going to perform NAD+ augmentation-related clinical studies. This meeting covered talks about NAD+ synthetic pathways, subcellular homeostasis of NAD+, the benefits of NAD+ augmentation from maternal milk to offspring, current clinical trials of the NAD+ precursor nicotinamide riboside (NR) on Ataxia-Telangiectasia (A-T), Parkinson's disease (PD), post-sepsis fatigue, as well as other potential NR-based clinical trials. Importantly, a consensus is emerging with respect to the design of clinical trials in order to measure meaningful parameters and ensure safety.

中文翻译：

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在转化研究中以 NAD+ 为目标，以缓解代谢压力和衰老引起的疾病和状况。

烟酰胺腺嘌呤二核苷酸 (NAD+) 通过调节能量生物发生、氧化还原稳态、细胞代谢以及通过与细胞凋亡和自噬途径的联系来仲裁细胞生存，在生命和健康中发挥着重要作用。实验室动物研究和早期临床测试揭示了 NAD+ 在衰老和健康长寿中的重要性。虽然基础研究人员和临床医生已经研究了 NAD+ 的分子机制和转化潜力，但在应用实验室科学来设计最有效的试验方面仍然存在重大差距。本次小型回顾基于 2019 年 10 月 28 日在挪威阿克斯胡斯大学医院举行的第三届 NO-Age 研讨会的议程和讨论。本次研讨会汇集了 NAD+ 的领先基础研究人员以及正在或即将进行的临床医生。进行 NAD+ 增强相关的临床研究。本次会议讨论了 NAD+ 合成途径、NAD+ 的亚细胞稳态、母乳中 NAD+ 增强对后代的益处、NAD+ 前体烟酰胺核苷 (NR) 对共济失调毛细血管扩张症 (AT) 和帕金森病 (PD) 的当前临床试验、脓毒症后疲劳，以及其他潜在的基于 NR 的临床试验。重要的是，为了测量有意义的参数并确保安全性，在临床试验的设计方面正在形成共识。